Study of the Antihypertensive Effect of Scorzonera undulata ssp. deliciosa in Albino Wistar Rats.

Cardiovascular & hematological agents in medicinal chemistry Pub Date : 2024-01-01 DOI:10.2174/0118715257243190231024164358

Ayoub Amssayef, Mohammed Ajebli, Mohamed Eddouks

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Abstract

Aims: The study aimed to investigate the antihypertensive activity of Scorzonera undulata ssp. deliciosa.

Background: Scorzonera undulata ssp deliciosa, locally known as "Guiz", is used in traditional medicine in Morocco as a diuretic and mainly against snake bites.

Objectives: This study investigated the possible antihypertensive effect of the aqueous extract of Scorzonera undulata (AESU).

Materials and methods: In the present study, the antihypertensive activity of AESU was tested in normotensive and hypertensive rats Results: The results indicated that AESU decreased the systolic, diastolic, and mean arterial blood pressure in hypertensive rats. The data revealed that AESU exerted its antihypertensive effect through vasodilatory properties. Interestingly, the study demonstrated that the vasorelaxation ability of AESU might be mediated through receptor-operated calcium channels (ROCCs). However, AESU dhad effect on inhibiting ACE-2.

Conclusion: The present study indicates the antihypertensive and vasorelaxant activities of AESU in hypertensive rats.

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白化Wistar大鼠体内Scorzonera undulata ssp. deliciosa的降压效果研究

研究目的：本研究旨在探讨 Scorzonera undulata ssp. deliciosa 的降压活性：背景：Scorzonera undulata ssp deliciosa 在当地被称为 "Guiz"，在摩洛哥的传统医学中被用作利尿剂，主要用于治疗蛇咬伤：材料与方法：本研究调查了未落叶山苍子水提取物（AESU）可能具有的降压作用：本研究在正常血压大鼠和高血压大鼠中测试了 AESU AUSU 的抗高血压活性：结果表明，AESU 能降低高血压大鼠的收缩压、舒张压和平均动脉血压。数据显示，AESU 通过扩张血管的特性发挥降压作用。有趣的是，研究表明 AESU 的血管舒张能力可能是通过受体操作钙通道（ROCCs）介导的。然而，AESU 对抑制 ACE-2 也有作用：本研究表明，AESU 对高血压大鼠具有降压和舒张血管的活性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Cardiovascular & hematological agents in medicinal chemistry

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