Effect of Ganoderma lucidum on serum lipid profiles: A systematic review and meta-analysis on animal studies.

IF 1.5 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

Journal of Research in Medical Sciences Pub Date : 2023-09-29 eCollection Date: 2023-01-01 DOI:10.4103/jrms.jrms_175_23

Maryam Aref, Mehri Khoshhali, Pouria Ghasemi, Shaghayegh Adeli, Motahar Heidari-Beni, Roya Kelishadi

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引用次数: 0

Abstract

Background: Ganoderma lucidum (G. lucidum) is one of the most popular edible mushrooms in the world which has various pharmacological components. Recently, some animal studies have investigated the lipid-lowering effects of G. lucidum and have shown contradictory results. This study aims to systematically review the effects of G. lucidum on lipid parameters in animal studies.

Materials and methods: A systematic search was conducted in the Medline database (PubMed), Scopus, Web of Science, Cochrane Library, and Google Scholar up to the end of January 2022. Only animal studies and all eligible randomized controlled trials (RCTs), including cluster RCTs and randomized crossover trials were included. The English language studies that assessed the effects of G. lucidum on lipid profiles including total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and very low-density lipoproteins (VLDL) were selected.

Results: Among 358 studies, 49 articles were included in the systematic review and meta-analysis. G. lucidum consumption was associated with decreased levels of TG (standardized mean difference [SMD] = -1.52, 95% CI: -1.79, -1.24), TC (SMD = -1.51, 95% CI: -1.75, -1.27), LDL-C (SMD = -2.03, 95% CI: -2.37, -1.69) and VLDL (SMD =-1.06, 95% CI: -1.638, -0.482). Furthermore, G. lucidum consumption was associated with increased levels of HDL-C (SMD = 1.03, 95% CI: 0.73, 1.33).

Conclusion: G. lucidum has favorable effects on TG, TC, LDL-C, HDL-C, and VLDL. Different doses of G. lucidum have various degrees of effectiveness on lipid profiles.

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灵芝对血清脂质的影响：动物研究的系统回顾和荟萃分析

背景：灵芝（Ganoderma lucidum）是世界上最受欢迎的食用菌之一，具有多种药理成分。最近，一些动物研究调查了灵芝的降血脂作用，结果却相互矛盾。本研究旨在系统回顾在动物实验中金针菇对血脂参数的影响：截至 2022 年 1 月底，在 Medline 数据库（PubMed）、Scopus、Web of Science、Cochrane Library 和 Google Scholar 中进行了系统检索。只纳入了动物研究和所有符合条件的随机对照试验（RCT），包括分组 RCT 和随机交叉试验。结果：在 358 项研究中，有 49 篇文章被收录：在 358 项研究中，有 49 篇文章被纳入系统综述和荟萃分析。食用绿巨人可降低 TG（标准化平均差 [SMD] =-1.52，95% CI：-1.79，-1.24）、TC（SMD =-1.51，95% CI：-1.75，-1.27）、LDL-C（SMD =-2.03，95% CI：-2.37，-1.69）和 VLDL（SMD =-1.06，95% CI：-1.638，-0.482）的水平。此外，食用绿巨人与高密度脂蛋白胆固醇水平的增加有关（SMD = 1.03，95% CI：0.73，1.33）：结论：绿芝对总胆固醇、总热胆固醇、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇和低密度脂蛋白胆固醇有良好的影响。不同剂量的鹿角胶对血脂有不同程度的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Research in Medical Sciences MEDICINE, GENERAL & INTERNAL-

CiteScore

2.60

自引率

6.20%

发文量

审稿时长

3-6 weeks

期刊介绍： Journal of Research in Medical Sciences, a publication of Isfahan University of Medical Sciences, is a peer-reviewed online continuous journal with print on demand compilation of issues published. The journal’s full text is available online at http://www.jmsjournal.net. The journal allows free access (Open Access) to its contents and permits authors to self-archive final accepted version of the articles on any OAI-compliant institutional / subject-based repository.