Lifestyle improvement and the reduced risk of cardiovascular disease: the China-PAR project.

IF 1.8 4区医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS

Journal of Geriatric Cardiology Pub Date : 2023-11-28 DOI:10.26599/1671-5411.2023.11.005

Ying-Ying Jiang, Fang-Chao Liu, Chong Shen, Jian-Xin Li, Ke-Yong Huang, Xue-Li Yang, Ji-Chun Chen, Xiao-Qing Liu, Jie Cao, Shu-Feng Chen, Ling Yu, Ying-Xin Zhao, Xian-Ping Wu, Lian-Cheng Zhao, Ying Li, Dong-Sheng Hu, Jian-Feng Huang, Xiang-Feng Lu, Dong-Feng Gu

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引用次数: 0

Abstract

Background: The benefits of healthy lifestyles are well recognized. However, the extent to which improving unhealthy lifestyles reduces cardiovascular disease (CVD) risk needs to be discussed. We evaluated the impact of lifestyle improvement on CVD incidence using data from the China-PAR project (Prediction for Atherosclerotic Cardiovascular Disease Risk in China).

Methods: A total of 12,588 participants free of CVD were followed up for three visits after the baseline examination. Changes in four lifestyle factors (LFs) (smoking, diet, physical activity, and alcohol consumption) were assessed through questionnaires from the baseline to the first follow-up visit. Cox proportional hazard models were used to estimate hazard ratios (HRs) and corresponding 95% confidence intervals (CIs). The risk advancement periods (RAPs: the age difference between exposed and unexposed participants reaching the same incident CVD risk) and population-attributable risk percentage (PAR%) were also calculated.

Results: A total of 909 incident CVD cases occurred over a median follow-up of 11.14 years. Compared with maintaining 0-1 healthy LFs, maintaining 3-4 healthy LFs was associated with a 40% risk reduction of incident CVD (HR = 0.60, 95% CI: 0.45-0.79) and delayed CVD risk by 6.31 years (RAP: -6.31 [-9.92, -2.70] years). The PAR% of maintaining 3-4 unhealthy LFs was 22.0% compared to maintaining 0-1 unhealthy LFs. Besides, compared with maintaining two healthy LFs, improving healthy LFs from 2 to 3-4 was associated with a 23% lower risk of CVD (HR = 0.77, 95% CI: 0.60-0.98).

Conclusions: Long-term sustenance of healthy lifestyles or improving unhealthy lifestyles can reduce and delay CVD risk.

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改善生活方式与降低心血管疾病风险：中国-PAR 项目。

背景：健康生活方式的益处已得到广泛认可。然而，改善不健康的生活方式能在多大程度上降低心血管疾病（CVD）风险还需要讨论。我们利用中国动脉粥样硬化性心血管疾病风险预测项目（China-PAR）的数据评估了改善生活方式对心血管疾病发病率的影响：方法：在基线检查后，对12588名无心血管疾病的参与者进行了三次随访。从基线检查到第一次随访，通过问卷调查评估了四种生活方式因素（吸烟、饮食、体力活动和饮酒）的变化。采用 Cox 比例危险模型估算危险比（HRs）和相应的 95% 置信区间（CIs）。此外，还计算了风险推进期（RAPs：达到相同心血管疾病发病风险的暴露参与者与未暴露参与者之间的年龄差异）和人口可归因风险百分比（PAR%）：在中位 11.14 年的随访期间，共发生了 909 例心血管疾病事件。与保持 0-1 个健康低密度脂蛋白血症患者相比，保持 3-4 个健康低密度脂蛋白血症患者的心血管疾病发病风险降低了 40%（HR = 0.60，95% CI：0.45-0.79），心血管疾病风险延迟了 6.31 年（RAP：-6.31 [-9.92, -2.70]年）。与维持 0-1 个不健康低密度脂蛋白相比，维持 3-4 个不健康低密度脂蛋白的 PAR% 为 22.0%。此外，与保持 2 个健康低频相比，将健康低频从 2 个增加到 3-4 个与心血管疾病风险降低 23% 相关（HR = 0.77，95% CI：0.60-0.98）：结论：长期保持健康的生活方式或改善不健康的生活方式可降低并延缓心血管疾病风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Geriatric Cardiology CARDIAC & CARDIOVASCULAR SYSTEMS-GERIATRICS & GERONTOLOGY

CiteScore

3.30

自引率

4.00%

发文量

1161

期刊介绍： JGC focuses on both basic research and clinical practice to the diagnosis and treatment of cardiovascular disease in the aged people, especially those with concomitant disease of other major organ-systems, such as the lungs, the kidneys, liver, central nervous system, gastrointestinal tract or endocrinology, etc.