Risk factors for empty follicle syndrome in assisted reproductive technology with gonadotropin-releasing hormone agonist trigger.

IF 2.7 3区医学 Q2 OBSTETRICS & GYNECOLOGY

Reproductive Medicine and Biology Pub Date : 2023-12-09 eCollection Date: 2023-01-01 DOI:10.1002/rmb2.12553

Daichi Inoue, Yoshihiko Sakakibara, Chiharu Ishida, Manami Kondo, Rie Mizuno, Masaya Saito, Shinichi Shibuya, Yoshiki Hashiba, Yoshimasa Asada

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引用次数: 0

Abstract

Purpose: To analyze whether response to the GnRH test is a predictor of empty follicle syndrome (EFS) and to analyze independent risk factors for EFS.

Methods: The GnRH test results of 3765 patients from 2016 to 2018 were used to define the reference range of the GnRH test. Risk factors for EFS were estimated by multivariate logistic analysis of 5282 cycles (5247 oocyte-retrieved cycles with GnRH agonist trigger and 35 cycles of EFS) conducted from 2016 to 2019.

Results: GnRH testing showed basal hormone values as follows: median LH 5.2 (95 percentile; 1.3-12.6) mIU/mL, LH 30 min 22.0 (6.8-57.1), basal FSH 7.3 (3.0-20.5), FSH 30 min 11.5 (5.1-30.4) and FSH/LH ratio 1.5 (0.6-4.1). Independent risk factors for EFS were antral follicle count (adjusted odds ratio; 0.94, 95% CI; 0.89-0.99), basal LH (0.78, 0.66-0.90), and days duration of ovarian stimulation (1.41, 1.21-1. 60). The respective thresholds were 8 for AFC, 5.0 for basal LH, and 16 days for duration.

Conclusions: LH 30 min values of the GnRH test did not predict EFS. Independent risk factors for EFS were AFC, basal LH and days duration of ovarian stimulation.

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使用促性腺激素释放激素激动剂触发辅助生殖技术的空卵泡综合征的风险因素。

目的：分析GnRH检测反应是否是空卵泡综合征（EFS）的预测指标，并分析EFS的独立风险因素：采用2016年至2018年3765名患者的GnRH检测结果来定义GnRH检测的参考范围。通过对2016年至2019年进行的5282个周期（5247个GnRH激动剂触发的卵母细胞检索周期和35个EFS周期）进行多变量Logistic分析，估计EFS的风险因素：GnRH检测显示基础激素值如下：中位LH 5.2（95百分位数；1.3-12.6）mIU/mL，LH 30分钟22.0（6.8-57.1），基础FSH 7.3（3.0-20.5），FSH 30分钟11.5（5.1-30.4），FSH/LH比值1.5（0.6-4.1）。EFS的独立风险因素是前卵泡计数（调整后的几率；0.94，95% CI；0.89-0.99）、基础LH（0.78，0.66-0.90）和卵巢刺激天数（1.41，1.21-1.60）。AFC的阈值分别为8，基础LH的阈值分别为5.0，持续时间的阈值分别为16天：结论：GnRH试验的LH 30分钟值不能预测EFS。EFS的独立风险因素是AFC、基础LH和卵巢刺激持续天数。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Reproductive Medicine and Biology Multiple-

CiteScore

5.70

自引率

5.90%

发文量

审稿时长

20 weeks

期刊介绍： Reproductive Medicine and Biology (RMB) is the official English journal of the Japan Society for Reproductive Medicine, the Japan Society of Fertilization and Implantation, the Japan Society of Andrology, and publishes original research articles that report new findings or concepts in all aspects of reproductive phenomena in all kinds of mammals. Papers in any of the following fields will be considered: andrology, endocrinology, oncology, immunology, genetics, function of gonads and genital tracts, erectile dysfunction, gametogenesis, function of accessory sex organs, fertilization, embryogenesis, embryo manipulation, pregnancy, implantation, ontogenesis, infectious disease, contraception, etc.