High-Intensity Focused Ultrasound Surgery for Tumor Ablation: A Review of Current Applications.

IF 5.6 Q1 ONCOLOGY
Alessandro De Maio, Giulia Alfieri, Monica Mattone, Pejman Ghanouni, Alessandro Napoli
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引用次数: 0

Abstract

The management of cancer with alternative approaches is a matter of clinical interest worldwide. High-intensity focused ultrasound (HIFU) surgery is a noninvasive technique performed under US or MRI guidance. The most studied therapeutic uses of HIFU involve thermal tissue ablation, demonstrating both palliative and curative potential. However, concurrent mechanical bioeffects also provide opportunities in terms of augmented drug delivery and immunosensitization. The safety and efficacy of HIFU integration with current cancer treatment strategies are being actively investigated in managing primary and secondary tumors, including cancers of the breast, prostate, pancreas, liver, kidney, and bone. Current primary HIFU indications are pain palliation, complete ablation of localized earlystage tumors, or debulking of unresectable late-stage cancers. This review presents the latest HIFU applications, from investigational to clinically approved, in the field of tumor ablation. Keywords: Ultrasound, Ultrasound-High Intensity Focused (HIFU), Interventional-MSK, Interventional-Body, Oncology, Technology Assessment, Tumor Response, MR Imaging © RSNA, 2023.

用于肿瘤消融的高强度聚焦超声手术:当前应用综述。
采用替代方法治疗癌症是全世界临床关注的问题。高强度聚焦超声(HIFU)手术是一种在 US 或 MRI 引导下进行的非侵入性技术。研究最多的 HIFU 治疗用途涉及热组织消融,显示出缓解和治疗的潜力。不过,同时产生的机械生物效应也为增强给药和免疫增敏提供了机会。在治疗原发性和继发性肿瘤(包括乳腺癌、前列腺癌、胰腺癌、肝癌、肾癌和骨癌)方面,目前正在积极研究 HIFU 与当前癌症治疗策略相结合的安全性和有效性。目前 HIFU 的主要适应症是减轻疼痛、完全消融局部早期肿瘤或清除无法切除的晚期癌症。本综述介绍了 HIFU 在肿瘤消融领域的最新应用,包括从研究到临床批准的应用。关键词超声波、超声波-高强度聚焦(HIFU)、介入-MSK、介入-全身、肿瘤学、技术评估、肿瘤反应、磁共振成像 © RSNA, 2023.
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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CiteScore
5.00
自引率
2.30%
发文量
0
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