Tumor necrosis factor alpha gene polymorphism affects the pattern of idiopathic nephrotic syndrome in Kuwaiti Arab children.

IF 1.8 4区 医学 Q2 PEDIATRICS
Amal A Al-Eisa, Maysoun Al Rushood, Sumedha Kashyap, Mohammad Z Haider
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引用次数: 0

Abstract

Objectives: TNF-α is a pro-inflammatory cytokine that has been implicated in many inflammatory diseases, but its association with idiopathic nephrotic syndrome (INS) is poorly understood. This study looked for an association of TNF-α gene polymorphisms with INS, as well as its effect on steroid responsiveness among Kuwaiti Arab children.

Methods: Genotypes of the TNF-a gene polymorphisms were analyzed using polymerase chain reaction-restriction fragment length polymorphism in 151 INS Kuwaiti Arab patients and 64 age and sex-matched controls. Clinical data of all subjects were reviewed.

Results: The heterozygous AG genotype was detected in 8.6% of INS patients compared 23.4% of the controls (p < 0.01). Comparing steroid responsiveness, AA genotype was significantly more common in steroid-sensitive nephrotic syndrome (SSNS) cases than steroid-resistant nephrotic syndrome (SRNS) patients (p = 0.001). However, AG genotype was significantly more common in SRNS patients compared to the SSNS cases (p = 0.001). No difference was found between these two subgroups in the GG genotype frequency.

Conclusion: AG genotype of TNF-a gene polymorphisms may be considered a suitable marker for INS disease among Kuwaiti children. Both AA and AG genotypes may be useful in predicting steroid responsiveness among these cases of Arab ethnicity. The findings might open the era for the use of genetic markers in the early treatment of NS.

肿瘤坏死因子α基因多态性影响科威特阿拉伯儿童特发性肾病综合征的模式。
研究目的TNF-α 是一种促炎细胞因子,与许多炎症性疾病有关,但其与特发性肾病综合征(INS)的关系却鲜为人知。本研究调查了 TNF-α 基因多态性与 INS 的关系,以及 TNF-α 基因多态性对科威特阿拉伯儿童类固醇反应性的影响:方法:利用聚合酶链式反应-限制性片段长度多态性分析了 151 名 INS 科威特阿拉伯患者和 64 名年龄和性别匹配的对照组中 TNF-a 基因多态性的基因型。对所有受试者的临床数据进行了审查:结果:在 8.6% 的 INS 患者中检测到杂合 AG 基因型,而在 23.4% 的对照组中检测到该基因型:TNF-a基因多态性的AG基因型可被视为科威特儿童INS疾病的合适标记物。AA和AG基因型可能有助于预测这些阿拉伯裔病例对类固醇的反应性。这些研究结果可能会开创将遗传标记用于 NS 早期治疗的时代。
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来源期刊
Journal of Tropical Pediatrics
Journal of Tropical Pediatrics 医学-热带医学
CiteScore
4.00
自引率
0.00%
发文量
97
审稿时长
6-12 weeks
期刊介绍: The Journal of Tropical Pediatrics provides a link between theory and practice in the field. Papers report key results of clinical and community research, and considerations of programme development. More general descriptive pieces are included when they have application to work preceeding elsewhere. The journal also presents review articles, book reviews and, occasionally, short monographs and selections of important papers delivered at relevant conferences.
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