In vitro fertilization pregnancy may cause fetal thymic volume involution: A case-control study.

IF 1.6 Q3 OBSTETRICS & GYNECOLOGY

International Journal of Reproductive Biomedicine Pub Date : 2023-11-24 eCollection Date: 2023-10-01 DOI:10.18502/ijrm.v21i10.14537

Nurgul Selin Kaya, Emine Seda Guvendag Guven, Suleyman Guven

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引用次数: 0

Abstract

Background: The effect of modern infertility treatment modalities on fetal thymic volume has not been well known.

Objective: 3-dimensional (3D) fetal thymus volumes of 18-24 wk in vitro fertilization (IVF) pregnancies and spontaneous pregnancy cases were compared.

Materials and methods: 135 cases were evaluated in this prospective case-control study. The study was conducted between July 2019 and July 2020 at a university hospital in Trabzon, Turkey. Fetal thymus volume was calculated in the pregnant cases included in the study with the help of the virtual organ computer-assisted analysis system included in the advanced ultrasonography system. The fetal thymus volumes were compared between pregnant women with IVF and spontaneous pregnant women.

Results: The fetal thymus size was significantly lower in the IVF pregnancy group than in spontaneous pregnancy cases (p $<$ 0.001). It was found that the fetal complications, such as non-reassuring fetal health status and requirement for neonatal intensive care, were higher in cases who became pregnant after IVF treatment. It was also found that the rate of any pregnancy complication was significantly higher in IVF pregnancy group (p = 0.02).

Conclusion: In light of these results, it may be concluded that small fetal thymus size may be another fetal complication of IVF pregnancies.

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体外受精妊娠可能导致胎儿胸腺体积萎缩：病例对照研究

背景：现代不孕症治疗方法对胎儿胸腺体积的影响尚不清楚：目的：比较18-24周体外受精（IVF）妊娠和自然妊娠病例的三维（3D）胎儿胸腺体积。材料与方法：这项前瞻性病例对照研究评估了135个病例。研究于 2019 年 7 月至 2020 年 7 月在土耳其特拉布宗的一家大学医院进行。在高级超声波成像系统中包含的虚拟器官计算机辅助分析系统的帮助下，对纳入研究的孕妇进行了胎儿胸腺体积计算。对试管婴儿孕妇和自然怀孕孕妇的胎儿胸腺体积进行了比较：结果：体外受精妊娠组的胎儿胸腺体积明显低于自然妊娠组（P 0.001）。结果发现，试管婴儿治疗后怀孕的病例中，胎儿并发症的发生率较高，如胎儿健康状况无法保证、需要新生儿重症监护等。研究还发现，试管婴儿妊娠组的妊娠并发症发生率明显更高（P = 0.02）：综上所述，胎儿胸腺过小可能是试管婴儿妊娠的另一种胎儿并发症。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Reproductive Biomedicine OBSTETRICS & GYNECOLOGY-

CiteScore

2.40

自引率

7.70%

发文量

审稿时长

16 weeks

期刊介绍： The International Journal of Reproductive BioMedicine (IJRM), formerly published as "Iranian Journal of Reproductive Medicine (ISSN: 1680-6433)", is an international monthly scientific journal for who treat and investigate problems of infertility and human reproductive disorders. This journal accepts Original Papers, Review Articles, Short Communications, Case Reports, Photo Clinics, and Letters to the Editor in the fields of fertility and infertility, ethical and social issues of assisted reproductive technologies, cellular and molecular biology of reproduction including the development of gametes and early embryos, assisted reproductive technologies in model system and in a clinical environment, reproductive endocrinology, andrology, epidemiology, pathology, genetics, oncology, surgery, psychology, and physiology. Emerging topics including cloning and stem cells are encouraged.