OFFSPRING: A SPRING Follow-Up Study Assessing the Efficacy of Maternal Probiotics and Allergic Disease in the Child.

IF 2.5 4区医学 Q3 ALLERGY

International Archives of Allergy and Immunology Pub Date : 2024-01-01 Epub Date: 2023-12-15 DOI:10.1159/000535179

Emma V Shipton, Katie Foxcroft, Marloes Dekker Nitert, H David McIntyre, Helen Barrett, Mimi Tang, Leonie Callaway

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引用次数: 0

Abstract

Introduction: There are a variety of factors that contribute to the development of allergic diseases in children, including environmental exposures during the maternal prenatal period. It has been proposed that probiotic supplementation during pregnancy could be used as a possible preventative measure to target childhood allergic disease.

Methods: Participants from a previously conducted prospective double-blind randomised control trial of probiotics versus placebo study (Study of PRrobiotics IN Gestation) were sent electronic questionnaires to complete about their child, who are now between 3 and 7 years of age. Demographic data and rates of allergic diseases were compared between the two groups.

Results: One hundred and seven women responded to the questionnaires. Between the two groups, there was no difference in the frequency of allergic diseases, with similar rates of eczema, asthma, and hospital presentations seen.

Conclusion: In this follow-up study, infants of mothers who were exposed to probiotics during their pregnancy do not appear to have any paediatric health advantages in terms of allergic diseases.

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OFFSPRING：评估母体益生菌功效和儿童过敏性疾病的 SPRING 跟踪研究。

导言：导致儿童过敏性疾病发生的因素有很多，其中包括母体产前的环境暴露。有人提出，孕期补充益生菌可作为一种针对儿童过敏性疾病的预防措施：方法：向先前进行的益生菌与安慰剂前瞻性双盲随机对照试验研究（妊娠期益生菌研究）的参与者发送电子问卷，让他们填写有关其子女的信息，这些子女目前年龄在 3 到 7 岁之间。两组的人口统计学数据和过敏性疾病发病率进行了比较：结果：有 107 名妇女回答了问卷。两组婴儿的过敏性疾病发病率没有差异，湿疹、哮喘和住院率相似：在这项跟踪研究中，母亲在怀孕期间服用益生菌的婴儿在过敏性疾病方面似乎没有任何儿科健康优势。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Archives of Allergy and Immunology 医学-过敏

CiteScore

5.60

自引率

3.60%

发文量

105

审稿时长

2 months

期刊介绍： ''International Archives of Allergy and Immunology'' provides a forum for basic and clinical research in modern molecular and cellular allergology and immunology. Appearing monthly, the journal publishes original work in the fields of allergy, immunopathology, immunogenetics, immunopharmacology, immunoendocrinology, tumor immunology, mucosal immunity, transplantation and immunology of infectious and connective tissue diseases.