A meta-analysis of Lactate Ringer's solution versus Normal Saline in the treatment of acute pancreatitis

IF 2.2 4区医学 Q3 GASTROENTEROLOGY & HEPATOLOGY

Gastroenterologia y hepatologia Pub Date : 2024-10-01 DOI:10.1016/j.gastrohep.2023.12.007

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Abstract

Fluid resuscitation is an important way in the treatment of acute pancreatitis (AP). This meta-analysis aimed to compare the safety and efficacy of Lactate Ringer's solution (LR) and Normal Saline (NS) in the treatment of patients with acute pancreatitis. Searched in PubMed, Web of Science Core Collection (Clarivate), Embase, Cochrane Library, CNKI, China Wanfang, and China VIP database. All randomized controlled clinical trials (RCTs) were identified. Six studies with 431 patients were included. Compared with NS, LR can significantly reduce the incidence of SIRS at 24 h, reduce the length of hospitalization, moderate–severe AP, ICU admission and local complications, especially pancreatic necrosis. It is safe and effective to choose LR for fluid resuscitation in AP, but due to the small number of included studies, multi-center and large-sample RCTs are still needed for further verification.

PROSPERO registration number: CRD42022322788.

查看原文本刊更多论文

乳酸林格氏液与正常生理盐水治疗急性胰腺炎的荟萃分析。

液体复苏是治疗急性胰腺炎（AP）的重要方法。本荟萃分析旨在比较乳酸林格氏液（LR）和正常生理盐水（NS）治疗急性胰腺炎患者的安全性和有效性。在 PubMed、Web of Science Core Collection (Clarivate)、Embase、Cochrane Library、CNKI、中国万方数据库和中国 VIP 数据库中检索。确定了所有随机对照临床试验（RCT）。共纳入 6 项研究，431 名患者。与 NS 相比，LR 可显著降低 24 小时内 SIRS 的发生率，缩短住院时间，减少中重度 AP、ICU 入院和局部并发症，尤其是胰腺坏死。AP患者选择LR进行液体复苏是安全有效的，但由于纳入的研究较少，仍需多中心、大样本的RCT研究进一步验证。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Gastroenterologia y hepatologia GASTROENTEROLOGY & HEPATOLOGY-

CiteScore

1.50

自引率

10.50%

发文量

147

审稿时长

48 days

期刊介绍： Gastroenterology and Hepatology is the first journal to cover the latest advances in pathology of the gastrointestinal tract, liver, pancreas, and bile ducts, making it an indispensable tool for gastroenterologists, hepatologists, internists and general practitioners.