Combined Prognostic Impact of Two Quick Frailty Assessments in Acute Heart Failure.

IF 3.1 3区医学 Q3 GERIATRICS & GERONTOLOGY

Gerontology Pub Date : 2024-01-01 Epub Date: 2023-12-18 DOI:10.1159/000534757

Mitsutoshi Oguri, Hideki Ishii, Rin Fujita, Hiroshi Takahashi, Toyoaki Murohara

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引用次数: 0

Abstract

Introduction: We aimed to investigate the prognostic impact of frailty (defined by the Study of Osteoporotic Fracture [SOF] index and the Clinical Frailty Scale [CFS]) in hospitalized patients with acute decompensated heart failure (HF).

Methods: A total of 1,053 patients over 75 years of age, who were primarily admitted to hospital with a diagnosis of acute decompensated HF, were enrolled. The prognostic value of frailty by the two tools for predicting all-cause mortality was analyzed using multivariate Cox regression models.

Results: The incidence of frailty was 57.1% when using the SOF index, 37.6% when using the CFS, and 23.3% when using both tools. Frailty, via the SOF index or CFS, was an independent predictor of all-cause mortality in model 1, after adjustment for significantly associated factors by univariate analysis (hazard ratio [HR] 1.38, 95% confidence interval [CI] 1.04-1.84, p = 0.027; HR 1.53, 95% CI 1.15-2.05, p = 0.003, respectively), and in model 2, after adjustment for previously reported prognostic factors (HR 1.42, 95% CI 1.07-1.89, p = 0.015; HR 1.56, 95% CI 1.17-2.07, p = 0.002, respectively). Compared to non-frail patients, frail patients via both tools had a significantly higher incidence of all-cause mortality in models 1 (adjusted HR 2.16, 95% CI 1.42-3.29, p < 0.001) and 2 (adjusted HR 2.30, 95% CI 1.51-3.50, p < 0.001).

Conclusions: Combined frailty screening using the SOF index and CFS contributed to stratify the risk of mortality in patients with acute decompensated HF.

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急性心力衰竭两种快速虚弱程度评估对预后的综合影响。

简介我们旨在研究虚弱（以骨质疏松性骨折研究[SOF]指数和临床虚弱量表[CFS]定义）对急性失代偿性心力衰竭（HF）住院患者预后的影响：方法：共招募了 1053 名 75 岁以上的患者，他们主要因诊断为急性失代偿性心力衰竭而入院。采用多变量考克斯回归模型分析了两种工具对预测全因死亡率的虚弱预后价值：结果：使用 SOF 指数的虚弱发生率为 57.1%，使用 CFS 的虚弱发生率为 37.6%，同时使用两种工具的虚弱发生率为 23.3%。在模型 1 中，通过 SOF 指数或 CFS 得出的虚弱程度是全因死亡率的独立预测因素，此前已通过单变量分析对明显相关的因素进行了调整（危险比 [HR] 1.38，95% 置信区间 [CI] 1.04-1.84，P =0.027；HR 1.53，95% CI 1.15-2.05，P =0.003），而在模型 2 中，在调整了之前报告的预后因素后（HR 1.42，95% CI 1.07-1.89，P =0.015；HR 1.56，95% CI 1.17-2.07，P =0.002）。与非虚弱患者相比，通过这两种工具筛查的虚弱患者在模型1中的全因死亡率明显更高（调整后HR为2.16，95% CI为1.42-3.29，P=0.015）：使用 SOF 指数和 CFS 联合进行虚弱筛查有助于对急性失代偿性心房颤动患者的死亡风险进行分层。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Gerontology 医学-老年医学

CiteScore

6.00

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： In view of the ever-increasing fraction of elderly people, understanding the mechanisms of aging and age-related diseases has become a matter of urgent necessity. ''Gerontology'', the oldest journal in the field, responds to this need by drawing topical contributions from multiple disciplines to support the fundamental goals of extending active life and enhancing its quality. The range of papers is classified into four sections. In the Clinical Section, the aetiology, pathogenesis, prevention and treatment of agerelated diseases are discussed from a gerontological rather than a geriatric viewpoint. The Experimental Section contains up-to-date contributions from basic gerontological research. Papers dealing with behavioural development and related topics are placed in the Behavioural Science Section. Basic aspects of regeneration in different experimental biological systems as well as in the context of medical applications are dealt with in a special section that also contains information on technological advances for the elderly. Providing a primary source of high-quality papers covering all aspects of aging in humans and animals, ''Gerontology'' serves as an ideal information tool for all readers interested in the topic of aging from a broad perspective.