Use of Antihypertensive Drugs and Arterial Stiffness in the Longitudinal Study of Adult Health (ELSA-Brasil).

IF 3.1 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Cardiovascular Drugs and Therapy Pub Date : 2025-04-01 Epub Date: 2023-12-12 DOI:10.1007/s10557-023-07529-x

Isabella Viana Gomes Schettini, Sandhi Maria Barreto, Luisa Campos Caldeira Brant, Antônio Luiz Pinho Ribeiro, José Geraldo Mill, Danyelle Romana Alves Rios, Roberta Carvalho Figueiredo

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引用次数: 0

Abstract

Objective: Evaluate the longitudinal association between BP control and the use of antihypertensive classes with arterial stiffness (AS) in Brazilian adults.

Methods: This study included 1830 participants with arterial hypertension (1092 participants with controlled BP and 738 participants with uncontrolled BP) from the Longitudinal Study of Adult Health (ELSA-Brasil). AS was assessed by pulse wave velocity (PWV) and pulse pressure (PP) at baseline and repeated after approximately 9 years. Associations between AS and BP control and the use of antihypertensives, diuretics, angiotensin-converting enzyme inhibitors (ACEI), AT1 receptor blockers (ARB), calcium channel blockers (CCB), and beta blockers (in the population with controlled BP), at baseline were investigated using linear mixed-effects models.

Results: Uncontrolled BP was associated with worse PWV and PP trajectory, respectively (β = 0.026 [0.008 to 0.036] / β = 0.273 [0.216 to 0.330]). Among the participants with controlled BP, using CCB (β = 0.031 [0.011 to 0.051]) was associated with a worse PWV trajectory, compared to not using this class and this combination, respectively.

Conclusion: BP control, regardless of the class of antihypertensive used is associated with a better AS trajectory, as assessed by PWV and PP. Among participants with controlled BP, the use of BCC, compared to not using this class, seems to be worse for the trajectory of PWV in individuals with arterial hypertension without cardiovascular disease. Further studies are needed to assess whether this effect results in a better prognosis for patients with arterial hypertension.

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成人健康纵向研究》（ELSA-Brasil）中抗高血压药物的使用与动脉僵化。

目的：评估巴西成年人血压控制和使用降压药与动脉僵化之间的纵向联系：评估巴西成年人血压控制和使用降压类药物与动脉僵化（AS）之间的纵向联系：这项研究纳入了成人健康纵向研究（ELSA-Brasil）中的 1830 名动脉高血压患者（其中 1092 人血压得到控制，738 人血压未得到控制）。通过脉搏波速度（PWV）和脉压（PP）对基线时的动脉高血压进行评估，并在大约 9 年后进行重复评估。使用线性混合效应模型研究了强直性脊柱炎与血压控制以及基线时使用降压药、利尿剂、血管紧张素转换酶抑制剂（ACEI）、AT1受体阻滞剂（ARB）、钙通道阻滞剂（CCB）和β受体阻滞剂（在血压控制人群中）之间的关系：结果：未控制血压分别与脉搏波速度和脉搏波速度轨迹较差有关（β = 0.026 [0.008 至 0.036] / β = 0.273 [0.216 至 0.330]）。在血压得到控制的参与者中，使用 CCB（β = 0.031 [0.011 至 0.051]）与不使用该类药物和该组合相比，脉搏波速度轨迹更差：结论：根据脉搏波速度和脉搏波密度评估，无论使用哪种降压药，血压控制都与较好的 AS 轨迹相关。在控制血压的参与者中，使用 BCC 与不使用该类降压药相比，似乎对无心血管疾病的动脉高血压患者的脉搏波速度轨迹更不利。还需要进一步的研究来评估这种影响是否会改善动脉高血压患者的预后。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cardiovascular Drugs and Therapy 医学-心血管系统

CiteScore

8.30

自引率

0.00%

发文量

110

审稿时长

4.5 months

期刊介绍： Designed to objectively cover the process of bench to bedside development of cardiovascular drug, device and cell therapy, and to bring you the information you need most in a timely and useful format, Cardiovascular Drugs and Therapy takes a fresh and energetic look at advances in this dynamic field. Homing in on the most exciting work being done on new therapeutic agents, Cardiovascular Drugs and Therapy focusses on developments in atherosclerosis, hyperlipidemia, diabetes, ischemic syndromes and arrhythmias. The Journal is an authoritative source of current and relevant information that is indispensable for basic and clinical investigators aiming for novel, breakthrough research as well as for cardiologists seeking to best serve their patients. Providing you with a single, concise reference tool acknowledged to be among the finest in the world, Cardiovascular Drugs and Therapy is listed in Web of Science and PubMed/Medline among other abstracting and indexing services. The regular articles and frequent special topical issues equip you with an up-to-date source defined by the need for accurate information on an ever-evolving field. Cardiovascular Drugs and Therapy is a careful and accurate guide through the maze of new products and therapies which furnishes you with the details on cardiovascular pharmacology that you will refer to time and time again.