Whole-genome resequencing reveals candidate genes associated with milk production trait in Guanzhong dairy goats

IF 16.4 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY
Jie Ni, Ming Xian, Yijie Ren, Lina Yang, Yu Li, Songmao Guo, Benkang Ran, Jianhong Hu
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引用次数: 0

Abstract

Milk production is one of the most important economic utility of goats. Guanzhong dairy goat is a local dairy goat in Shaanxi Province of China and has high milk yield and quality. However, there are relatively few studies on molecular markers of milk production traits in Guanzhong dairy goats. In this study, we sequenced the whole genomes of 20 Guanzhong dairy goats, 10 of which had high milk yield (HM) and 10 of which had low milk yield (LM). We detected candidate signatures of selection in HM goats using Fst and π-ratio statistics and identified several candidate genes including ANPEP, ADRA1A and PRKG1 associated with milk production. Our results provide the basis for molecular breeding of milk production traits in Guanzhong dairy goats.

全基因组测序揭示关中奶山羊产奶性状相关候选基因
产奶是山羊最重要的经济价值之一。关中奶山羊是中国陕西省的地方奶山羊,产奶量高,奶质好。然而,有关关中奶山羊产奶性状分子标记的研究相对较少。在本研究中,我们对 20 只关中奶山羊进行了全基因组测序,其中 10 只为高产奶山羊(HM),10 只为低产奶山羊(LM)。我们利用Fst和π-ratio统计量检测了高产奶量奶山羊的候选选择特征,并确定了几个与产奶量相关的候选基因,包括ANPEP、ADRA1A和PRKG1。我们的研究结果为关中奶山羊产奶性状的分子育种提供了依据。
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来源期刊
Accounts of Chemical Research
Accounts of Chemical Research 化学-化学综合
CiteScore
31.40
自引率
1.10%
发文量
312
审稿时长
2 months
期刊介绍: Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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