Effect of tomato, tomato-derived products and lycopene on metabolic inflammation: from epidemiological data to molecular mechanisms

IF 5.1 2区医学 Q1 NUTRITION & DIETETICS

Nutrition Research Reviews Pub Date : 2023-12-18 DOI:10.1017/s095442242300029x

Jean-François Landrier, Thomas Breniere, Léa Sani, Charles Desmarchelier, Lourdes Mounien, Patrick Borel

{"title":"Effect of tomato, tomato-derived products and lycopene on metabolic inflammation: from epidemiological data to molecular mechanisms","authors":"Jean-François Landrier, Thomas Breniere, Léa Sani, Charles Desmarchelier, Lourdes Mounien, Patrick Borel","doi":"10.1017/s095442242300029x","DOIUrl":null,"url":null,"abstract":"The goal of this narrative review is to summarize the current knowledge and limitations related to the anti-inflammatory effects of tomato, tomato-derived products and lycopene in the context of metabolic inflammation associated to cardiometabolic diseases. The potential of tomato and tomato derived products supplementation is supported by animal and in vitro studies. In addition, intervention studies provide arguments in favor of a limitation of metabolic inflammation. This is also the case of observational studies depicting inverse association between plasma lycopene levels and inflammation. Nevertheless, current data of intervention studies are mixed concerning the anti-inflammatory effect of tomato and tomato-derived products and are not in favor of an anti-inflammatory effect of pure lycopene in humans. From epidemiological to mechanistic studies, this review aims to identify limitations of the current knowledge and gaps that remain to be filled to improve our comprehension in contrasted anti-inflammatory effects of tomato, tomato-derived products and pure lycopene.","PeriodicalId":54703,"journal":{"name":"Nutrition Research Reviews","volume":"101 1","pages":""},"PeriodicalIF":5.1000,"publicationDate":"2023-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nutrition Research Reviews","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1017/s095442242300029x","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"NUTRITION & DIETETICS","Score":null,"Total":0}

引用次数: 0

Abstract

The goal of this narrative review is to summarize the current knowledge and limitations related to the anti-inflammatory effects of tomato, tomato-derived products and lycopene in the context of metabolic inflammation associated to cardiometabolic diseases. The potential of tomato and tomato derived products supplementation is supported by animal and in vitro studies. In addition, intervention studies provide arguments in favor of a limitation of metabolic inflammation. This is also the case of observational studies depicting inverse association between plasma lycopene levels and inflammation. Nevertheless, current data of intervention studies are mixed concerning the anti-inflammatory effect of tomato and tomato-derived products and are not in favor of an anti-inflammatory effect of pure lycopene in humans. From epidemiological to mechanistic studies, this review aims to identify limitations of the current knowledge and gaps that remain to be filled to improve our comprehension in contrasted anti-inflammatory effects of tomato, tomato-derived products and pure lycopene.

查看原文本刊更多论文

番茄、番茄衍生产品和番茄红素对代谢性炎症的影响：从流行病学数据到分子机制

这篇叙述性综述的目的是总结目前有关番茄、番茄衍生产品和番茄红素在与心脏代谢疾病相关的代谢炎症方面的抗炎作用的知识和局限性。补充番茄和番茄衍生产品的潜力得到了动物和体外研究的支持。此外，干预研究也为限制代谢性炎症提供了论据。观察性研究也表明，血浆番茄红素水平与炎症呈反向关系。不过，关于番茄和番茄衍生产品的抗炎作用，目前的干预研究数据喜忧参半，并不支持纯番茄红素对人体的抗炎作用。从流行病学研究到机理研究，本综述旨在找出当前知识的局限性和有待填补的空白，以提高我们对番茄、番茄衍生产品和纯番茄红素抗炎效果对比的理解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Nutrition Research Reviews 医学-营养学

CiteScore

16.10

自引率

1.80%

发文量

期刊介绍： Nutrition Research Reviews offers a comprehensive overview of nutritional science today. By distilling the latest research and linking it to established practice, the journal consistently delivers the widest range of in-depth articles in the field of nutritional science. It presents up-to-date, critical reviews of key topics in nutrition science advancing new concepts and hypotheses that encourage the exchange of fundamental ideas on nutritional well-being in both humans and animals.