Application potential of senolytics in clinical treatment

IF 4.4 4区 医学 Q1 GERIATRICS & GERONTOLOGY
Tiantian Li, Shiyuan Li, Kefeng Ma, Jinming Kong
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引用次数: 0

Abstract

Of the factors studied in individual ageing, the accumulation of senescent cells has been considered as an essential cause of organ degeneration to eventually initiate age-related diseases. Cellular senescence is attributed to the accumulation of damage for an inducement in the activation of cell cycle inhibitory pathways, resulting the cell permanently withdraw from the cell proliferation cycle. Further, senescent cells will activate the inflammatory factor secretion pathway to promote the development of various age-related diseases. Senolytics, a small molecule compound, can delay disease development and extend mammalian lifespan. The evidence from multiple trials shows that the targeted killing of senescent cells has a significant clinical application for the treatment of age-related diseases. In addition, senolytics are also significant for the development of ageing research in solid organ transplantation, which can fully develop the potential of elderly organs and reduce the age gap between demand and supply. We conclude that the main characteristics of cellular senescence, the anti-ageing drug senolytics in the treatment of chronic diseases and organ transplantation, and the latest clinical progress of related researches in order to provide a theoretical basis for the prevention and treatment of ageing and related diseases.

Abstract Image

衰老剂在临床治疗中的应用潜力
在研究的个体衰老因素中,衰老细胞的积累被认为是器官退化的重要原因,最终引发与年龄有关的疾病。细胞衰老是由于损伤的积累诱发了细胞周期抑制途径的激活,导致细胞永久退出细胞增殖周期。此外,衰老细胞还会激活炎症因子分泌途径,促进各种老年相关疾病的发生。衰老素是一种小分子化合物,可以延缓疾病的发展,延长哺乳动物的寿命。来自多项试验的证据表明,有针对性地杀死衰老细胞在治疗老年相关疾病方面具有重要的临床应用价值。此外,衰老素对实体器官移植中的衰老研究发展也具有重要意义,可以充分开发老年器官的潜力,缩小供需之间的年龄差距。我们总结了细胞衰老的主要特征、抗衰老药物senolytics在慢性疾病治疗和器官移植中的应用,以及相关研究的最新临床进展,以期为老龄化及相关疾病的防治提供理论依据。
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来源期刊
Biogerontology
Biogerontology 医学-老年医学
CiteScore
8.00
自引率
4.40%
发文量
54
审稿时长
>12 weeks
期刊介绍: The journal Biogerontology offers a platform for research which aims primarily at achieving healthy old age accompanied by improved longevity. The focus is on efforts to understand, prevent, cure or minimize age-related impairments. Biogerontology provides a peer-reviewed forum for publishing original research data, new ideas and discussions on modulating the aging process by physical, chemical and biological means, including transgenic and knockout organisms; cell culture systems to develop new approaches and health care products for maintaining or recovering the lost biochemical functions; immunology, autoimmunity and infection in aging; vertebrates, invertebrates, micro-organisms and plants for experimental studies on genetic determinants of aging and longevity; biodemography and theoretical models linking aging and survival kinetics.
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