Quantitative CT Evaluation of Bone Mineral Density in the Thoracic Spine on 18F-Fluorocholine PET/CT Imaging in Patients With Primary Hyperparathyroidism

IF 1.7 4区 医学 Q4 ENDOCRINOLOGY & METABOLISM
Erik T. te Beek , Chris P.W. van Duijnhoven , Riemer H.J.A. Slart , Joop P. van den Bergh , Marc R.J. ten Broek
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引用次数: 0

Abstract

Introduction: Measurement of bone mineral density (BMD) with quantitative CT (QCT) carries several advantages over other densitometric techniques, including superior assessment of the spine. As most QCT studies evaluated the lumbar spine, measurements of the thoracic spine are limited. We performed QCT analysis of the thoracic spine in a cohort of patients with primary hyperparathyroidism. Materials and methods: This study was a retrospective QCT analysis of the thoracic spine on 18F-fluorocholine PET/CT scans in patients with primary hyperparathyroidism patients between March 2018 and December 2022. Correlations between QCT-derived BMD or Hounsfield units (HU) and demographic data, laboratory parameters, results from histopathological examination after parathyroidectomy and results of DXA imaging were analyzed, when available. Results: In 189 patients, mean QCT-derived BMD at the thoracic spine was 85.6 mg/cm3. Results from recent DXA were available in 122 patients. Mean thoracic QCT-derived BMD and HU were significantly correlated with DXA-derived BMD in lumbar spine, total hip and femoral neck and with the lowest T-score at DXA imaging. Only weak correlations were found with BMI or 18F-fluorocholine uptake, while no significant correlations were found with adenoma weight, PTH or calcium levels. Conclusion: Our study confirms correlation between QCT-derived BMD in the thoracic spine with age and DXA-derived BMD measurements within a population of patients with primary hyperparathyroidism. Establishment of reference BMD values for individual thoracic vertebrae, may allow direct osteoporosis classification on thoracic CT imaging.

原发性甲状旁腺功能亢进症患者胸椎骨矿密度的18F-氟胆碱PET/CT成像定量CT评估
引言与其他密度测量技术相比,用定量 CT(QCT)测量骨矿密度(BMD)具有多项优势,包括对脊柱的评估效果更佳。由于大多数 QCT 研究评估的是腰椎,因此对胸椎的测量有限。我们对原发性甲状旁腺功能亢进症患者队列中的胸椎进行了 QCT 分析。材料和方法本研究是对 2018 年 3 月至 2022 年 12 月期间原发性甲状旁腺功能亢进症患者的 18F - 氟胆碱 PET/CT 扫描中胸椎的 QCT 进行回顾性分析。分析了 QCT 导出的 BMD 或 Hounsfield 单位(HU)与人口统计学数据、实验室参数、甲状旁腺切除术后组织病理学检查结果以及 DXA 成像结果(如有)之间的相关性。有 122 名患者获得了近期 DXA 的结果。胸椎平均 QCT 导出 BMD 和 HU 与腰椎、全髋和股骨颈的 DXA 导出 BMD 以及 DXA 成像的最低 T 评分显著相关。结论:我们的研究证实,在原发性甲状旁腺功能亢进症患者群体中,胸椎的 QCT 导出 BMD 与年龄和 DXA 导出 BMD 测量值之间存在相关性。为单个胸椎建立参考 BMD 值,可以通过胸部 CT 成像直接对骨质疏松症进行分类。
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来源期刊
Journal of Clinical Densitometry
Journal of Clinical Densitometry 医学-内分泌学与代谢
CiteScore
4.90
自引率
8.00%
发文量
92
审稿时长
90 days
期刊介绍: The Journal is committed to serving ISCD''s mission - the education of heterogenous physician specialties and technologists who are involved in the clinical assessment of skeletal health. The focus of JCD is bone mass measurement, including epidemiology of bone mass, how drugs and diseases alter bone mass, new techniques and quality assurance in bone mass imaging technologies, and bone mass health/economics. Combining high quality research and review articles with sound, practice-oriented advice, JCD meets the diverse diagnostic and management needs of radiologists, endocrinologists, nephrologists, rheumatologists, gynecologists, family physicians, internists, and technologists whose patients require diagnostic clinical densitometry for therapeutic management.
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