Hydroalkylation of 1,1-Diarylalkenes Mediated by Magnesium Hydride in Ethereal Solvents

IF 1.5 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Helvetica Chimica Acta Pub Date : 2023-12-14 DOI:10.1002/hlca.202300212

Nattawadee Chaisan, Eugene Yew Kun Tan, Shunsuke Chiba

引用次数: 0

Abstract

A method for the hydroalkylation of 1,1-diarylalkenes has been developed using magnesium hydride (MgH₂) generated in situ by the solvothermal treatment of magnesium iodide (MgI₂) with sodium hydride (NaH) in ethereal solvents. The process is initiated by the hydromagnesiation of 1,1-diarylalkenes with MgH₂ to generate 1,1-diarylethylmagnesium species, which are immediately alkylated with ethereal solvents to construct a diaryl quaternary carbon center in the hydroalkylation products.

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乙太溶剂中氢化镁介导的 1,1-二芳基烯烃氢烷基化反应

利用碘化镁（MgI2）与氢化钠（NaH）在乙醚溶剂中进行溶解热处理而就地生成的氢化镁（MgH2），开发出了一种 1,1-二芳基烯烃的氢烷基化方法。该工艺通过 MgH2 对 1,1-二芳基烯烃进行水镁化反应来生成 1,1-二芳基镁，然后立即用乙醚溶剂对其进行烷基化反应，从而在水烷基化产物中形成二芳基季碳中心。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Helvetica Chimica Acta 化学-化学综合

CiteScore

3.00

自引率

0.00%

发文量

审稿时长

2.3 months

期刊介绍： Helvetica Chimica Acta, founded by the Swiss Chemical Society in 1917, is a monthly multidisciplinary journal dedicated to the dissemination of knowledge in all disciplines of chemistry (organic, inorganic, physical, technical, theoretical and analytical chemistry) as well as research at the interface with other sciences, where molecular aspects are key to the findings. Helvetica Chimica Acta is committed to the publication of original, high quality papers at the frontier of scientific research. All contributions will be peer reviewed with the highest possible standards and published within 3 months of receipt, with no restriction on the length of the papers and in full color.