Structural changes in layers of lipid mixtures at low surface tensions

IF 3.4 3区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Chemistry and Physics of Lipids Pub Date : 2023-12-12 DOI:10.1016/j.chemphyslip.2023.105365

A.G. Bykov , M.A. Panaeva , O.Y. Milyaeva , A.V. Michailov , A.R. Rafikova , E. Guzman , R. Rubio , R. Miller , B.A. Noskov

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Abstract

Layers of pulmonary lipids on an aqueous substrate at non-equilibrium conditions can decrease the surface tension of water to quite low values. This is connected with different relaxation processes occurring at the interface and the associated changes in the surface layer structure. Results of measurements by the combination of methods like surface rheology, ellipsometry, Brewster angle microscopy, and IRRAS for spread layers of lipid mixtures open a possibility to specify the dynamics of structural changes at conditions close to the physiological state. At sufficiently low surface tension values (below 5 mN/m) significant changes in the ellipsometric signal were observed for pure DPPC layers, which can be related to a transition from 2D to 3D structures caused by the layer folding. The addition of other lipids can accelerate the relaxation processes connected with squeezing-out of molecules or multilayer stacks formation hampering thereby a decrease of surface tension down to low values corresponding to the folding of the monolayer.

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低表面张力下脂质混合物层的结构变化

在非平衡条件下，水基上的肺脂层可将水的表面张力降至相当低的值。这与界面上发生的不同弛豫过程以及表层结构的相关变化有关。结合表面流变学、椭偏仪、布儒斯特角显微镜和 IRRAS 等方法对脂质混合物铺展层进行测量的结果，为明确在接近生理状态的条件下结构变化的动态提供了可能。在足够低的表面张力值（低于 5 mN/m）下，纯 DPPC 层的椭偏仪信号发生了显著变化，这可能与层折叠引起的二维结构向三维结构的转变有关。添加其他脂类会加速与分子挤出或多层堆叠形成有关的松弛过程，从而阻碍表面张力降低到与单层折叠相应的低值。

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来源期刊

Chemistry and Physics of Lipids 生物-生化与分子生物学

CiteScore

7.60

自引率

2.90%

发文量

审稿时长

40 days

期刊介绍： Chemistry and Physics of Lipids publishes research papers and review articles on chemical and physical aspects of lipids with primary emphasis on the relationship of these properties to biological functions and to biomedical applications. Accordingly, the journal covers: advances in synthetic and analytical lipid methodology; mass-spectrometry of lipids; chemical and physical characterisation of isolated structures; thermodynamics, phase behaviour, topology and dynamics of lipid assemblies; physicochemical studies into lipid-lipid and lipid-protein interactions in lipoproteins and in natural and model membranes; movement of lipids within, across and between membranes; intracellular lipid transfer; structure-function relationships and the nature of lipid-derived second messengers; chemical, physical and functional alterations of lipids induced by free radicals; enzymatic and non-enzymatic mechanisms of lipid peroxidation in cells, tissues, biofluids; oxidative lipidomics; and the role of lipids in the regulation of membrane-dependent biological processes.