Precision cardiac targeting: empowering curcumin therapy through smart exosome-mediated drug delivery in myocardial infarction

IF 5.6 1区医学 Q1 MATERIALS SCIENCE, BIOMATERIALS

Regenerative Biomaterials Pub Date : 2023-12-14 DOI:10.1093/rb/rbad108

Ming Chen, Shengnan Wang, Yihuan Chen, Han Shen, Lei Chen, Liang Ding, Qingsong Tang, Ziying Yang, Weiqian Chen, Zhenya Shen

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引用次数: 0

Abstract

Nanoparticle-mediated drug delivery has emerged as a highly promising and effective therapeutic approach for addressing myocardial infarction. However, clinical translation tends to be a failure due to low cardiac retention as well as liver and spleen entrapment in previous therapies. Herein, we report a two-step exosome delivery system, which precludes internalization by the mononuclear phagocyte system before the delivery of therapeutic cardiac targeting exosomes (ExoCTP). Importantly, curcumin released by ExoCTP diminishes reactive oxygen species over-accumulation in ischemic myocardium, as well as serum levels of lactate dehydrogenase, malonyldialdehyde, superoxide dismutase, and glutathione, indicating better antioxidant capacity than free curcumin. Finally, our strategy was proven to greatly potentiate the delivery and therapeutic efficacy of curcumin without systemic toxicity. Taken together, our smart exosome-mediated drug delivery strategy can serve either as therapeutics alone or in combination with other drugs for effective heart targeting and subsequent wound healing.

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精准的心脏靶向治疗：通过智能外泌体介导的心肌梗死药物输送增强姜黄素治疗的能力

纳米颗粒介导的药物输送已成为治疗心肌梗塞的一种极具前景的有效治疗方法。然而，由于以往疗法的心脏保留率低以及肝脏和脾脏夹带药物，临床转化往往失败。在此，我们报告了一种两步外泌体递送系统，该系统在递送治疗性心脏靶向外泌体（ExoCTP）之前排除了单核吞噬细胞系统的内化。重要的是，ExoCTP 释放的姜黄素能减少缺血心肌中活性氧的过度积累，并降低血清中乳酸脱氢酶、丙二醛、超氧化物歧化酶和谷胱甘肽的水平，这表明姜黄素的抗氧化能力优于游离姜黄素。最后，我们的策略被证明能大大提高姜黄素的递送和疗效，且无全身毒性。综上所述，我们的智能外泌体介导的药物递送策略既可以单独作为治疗药物，也可以与其他药物联合使用，从而有效地靶向心脏并促进伤口愈合。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Regenerative Biomaterials Materials Science-Biomaterials

CiteScore

7.90

自引率

16.40%

发文量

审稿时长

10 weeks

期刊介绍： Regenerative Biomaterials is an international, interdisciplinary, peer-reviewed journal publishing the latest advances in biomaterials and regenerative medicine. The journal provides a forum for the publication of original research papers, reviews, clinical case reports, and commentaries on the topics relevant to the development of advanced regenerative biomaterials concerning novel regenerative technologies and therapeutic approaches for the regeneration and repair of damaged tissues and organs. The interactions of biomaterials with cells and tissue, especially with stem cells, will be of particular focus.