Correlation between Carotid Blood Flow Velocity and Total Magnetic Resonance Imaging Burden of Cerebral Small Vessel Disease in Patients with Recent Small Subcortical Infarcts

IF 2 4区医学 Q3 CLINICAL NEUROLOGY

Current neurovascular research Pub Date : 2023-12-15 DOI:10.2174/0115672026285373231120054627

Yi-Jun lv, Min Zhang, Wen-Wei Yun, Qing-Xiu Zhang, Jing-Wei LI

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引用次数: 0

Abstract

Background: The common and internal carotid arteries are the upstream vessels of the small cerebral vessels. The relationship between hemodynamic changes in the significant cervical vessels and cerebral small vessel disease (CSVD) remains uncertain. This research sought to analyze the correlation between carotid blood flow velocity and the total magnetic resonance imaging (MRI) burden of CSVD in patients with recent small subcortical infarcts (RSSIs). background: The common and internal carotid arteries are the upstream vessels of the small cerebral vessels. The relationship between hemodynamic changes in the significant cervical vessels and cerebral small vessel disease (CSVD) remains uncertain. Methods: Data were gathered from individuals diagnosed with RSSIs admitted to Changzhou Second People's Hospital between January 2022 and June 2023. Brain MRI was performed on every patient to determine the overall MRI burden of CSVD, along with carotid duplex ultrasound to evaluate carotid blood flow velocity and pulsatility index (PI) of the common carotid (CCA) and internal carotid (ICA) arteries. The association between carotid blood flow velocity and the total MRI load of CSVD was examined using univariate and multivariate analyses. objective: This research sought to analyze the correlation between carotid blood flow velocity and the total magnetic resonance imaging (MRI) burden of CSVD in patients with recent small subcortical infarcts(RSSIs). Results: For our investigation, 272 individuals with RSSIs were screened. 82 individuals had a moderate to severe load of CSVD, while 190 participants showed a mild burden. Patients with moderate to severe burden of CSVD had lower end-diastolic velocity (EDV) and higher PI in CCA and ICA than those with mild load (P < 0.001). After adjusting for variables like age, hypertension, systolic blood pressure, and blood homocysteine levels, multivariate logistic regression analysis showed that EDV in CCA (OR, 0.894; P = 0.011), PI in CCA (OR, 5.869; P = 0.017), EDV in ICA (OR, 0.909; P = 0.008), and PI in ICA (OR, 5.324; P = 0.041) were independently related to moderate to severe CSVD burden. Spearman correlation analysis showed that EDV in CCA and ICA was negatively related to the total MRI load of CSVD in patients with RSSIs (P < 0.001). PI in CCA and ICA was positively associated with the whole MRI load of CSVD (P < 0.001). Conclusion: Low carotid blood flow velocity and high carotid pulsatility index are independently associated with moderate to severe burden of CSVD. other: none

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近期皮层下小梗死患者颈动脉血流速度与磁共振成像中脑小血管疾病总负担之间的相关性

背景：颈总动脉和颈内动脉是大脑小血管的上游血管。颈部重要血管的血流动力学变化与脑小血管疾病（CSVD）之间的关系仍不确定。本研究试图分析近期皮层下小梗死（RSSI）患者颈动脉血流速度与 CSVD 总磁共振成像（MRI）负荷之间的相关性：颈总动脉和颈内动脉是小脑血管的上游血管。显性颈内血管的血流动力学变化与大脑小血管疾病（CSVD）之间的关系仍不确定。研究方法收集2022年1月至2023年6月期间常州市第二人民医院收治的RSSI患者的数据。对每位患者进行脑磁共振成像检查，以确定CSVD的总体磁共振成像负荷，同时进行颈动脉双相超声检查，以评估颈总动脉（CCA）和颈内动脉（ICA）的颈动脉血流速度和搏动指数（PI）。通过单变量和多变量分析，研究了颈动脉血流速度与 CSVD MRI 总负荷之间的关联：本研究旨在分析近期皮层下小梗死（RSSI）患者颈动脉血流速度与 CSVD 的磁共振成像（MRI）总负荷之间的相关性。研究结果我们共筛查了 272 名 RSSI 患者。其中 82 人有中度至重度 CSVD 负荷，190 人有轻度 CSVD 负荷。与轻度CSVD患者相比，中重度CSVD患者的舒张末期速度（EDV）较低，CCA和ICA的PI较高（P< 0.001）。在对年龄、高血压、收缩压和血同型半胱氨酸水平等变量进行调整后，多变量逻辑回归分析表明，CCA 的 EDV（OR，0.894；P = 0.011）、CCA 的 PI（OR，5.869；P = 0.017）、ICA 的 EDV（OR，0.909；P = 0.008）和 ICA 的 PI（OR，5.324；P = 0.041）与中度至重度 CSVD 负荷独立相关。斯皮尔曼相关分析表明，CCA和ICA的EDV与RSSI患者CSVD的MRI总负荷呈负相关（P < 0.001）。CCA和ICA的PI与CSVD的MRI总负荷呈正相关（P <0.001）。结论低颈动脉血流速度和高颈动脉搏动指数与中度至重度 CSVD 负荷独立相关。其他：无

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来源期刊

Current neurovascular research 医学-临床神经学

CiteScore

3.80

自引率

9.50%

发文量

审稿时长

3 months

期刊介绍： Current Neurovascular Research provides a cross platform for the publication of scientifically rigorous research that addresses disease mechanisms of both neuronal and vascular origins in neuroscience. The journal serves as an international forum publishing novel and original work as well as timely neuroscience research articles, full-length/mini reviews in the disciplines of cell developmental disorders, plasticity, and degeneration that bridges the gap between basic science research and clinical discovery. Current Neurovascular Research emphasizes the elucidation of disease mechanisms, both cellular and molecular, which can impact the development of unique therapeutic strategies for neuronal and vascular disorders.