Genome-wide association studies for loin muscle area, loin muscle depth and backfat thickness in DLY pigs

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2023-12-15 DOI:10.1111/age.13386

Xiang Zhao, Yibin Qiu, Fanming Meng, Zhanwei Zhuang, Donglin Ruan, Jie Wu, Fucai Ma, Enqin Zheng, Gengyuan Cai, Jie Yang, Ming Yang, Zhenfang Wu

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引用次数: 0

Abstract

This study aimed at identifying genes associated with loin muscle area (LMA), loin muscle depth (LMD) and backfat thickness (BFT). We performed single-trait and multi-trait genome-wide association studies (GWASs) after genotyping 685 Duroc × (Landrace × Yorkshire) (DLY) pigs using the Geneseek Porcine 50K SNP chip. In the single-trait GWASs, we identified two, eight and two significant SNPs associated with LMA, LMD and BFT, respectively, and searched genes within the 1 Mb region near the significant SNPs with relevant functions as candidate genes. Consequently, we identified one (DOCK5), three (PID1, PITX2, ELOVL6) and three (CCR1, PARP14, CASR) promising candidate genes for LMA, LMD and BFT, respectively. Moreover, the multi-trait GWAS identified four significant SNPs associated with the three traits. In conclusion, the GWAS analysis of LMA, LMD and BFT in a DLY pig population identified several associated SNPs and candidate genes, further deepening our understanding of the genetic basis of these traits, and they may be useful for marker-assisted selection to improve the three traits in DLY pigs.

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DLY 猪腰部肌肉面积、腰部肌肉深度和背膘厚度的全基因组关联研究

本研究旨在确定与腰肌面积（LMA）、腰肌深度（LMD）和背膘厚度（BFT）相关的基因。我们使用 Geneseek 猪 50K SNP 芯片对 685 头杜洛克×（兰德赛×约克夏）（DLY）猪进行基因分型后，进行了单性状和多性状全基因组关联研究（GWAS）。在单性状 GWAS 中，我们分别发现了 2 个、8 个和 2 个与 LMA、LMD 和 BFT 相关的显著 SNP，并在显著 SNP 附近的 1 Mb 区域内搜索了具有相关功能的基因作为候选基因。结果，我们分别发现了1个（DOCK5）、3个（PID1、PITX2、ELOVL6）和3个（CCR1、PARP14、CASR）有望成为LMA、LMD和BFT的候选基因。此外，多性状 GWAS 还发现了 4 个与这三个性状相关的显著 SNPs。总之，在DLY猪群体中对LMA、LMD和BFT的GWAS分析发现了多个相关的SNPs和候选基因，进一步加深了我们对这些性状遗传基础的理解，它们可能有助于标记辅助选择以改善DLY猪的这三个性状。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.