{"title":"Irisin limits amyloid-β buildup in Alzheimer’s disease","authors":"Mychael V. Lourenco","doi":"10.1016/j.tem.2023.11.006","DOIUrl":null,"url":null,"abstract":"<p><span>Mounting evidence suggests that physical exercise protects the brain against neurodegenerative disease. In a recent paper in </span><em>Neuron</em>, <span>Kim <em>et al</em>.</span><svg aria-label=\"Opens in new window\" focusable=\"false\" height=\"8px\" viewbox=\"0 0 8 8\" width=\"8px\"><path d=\"M1.12949 2.1072V1H7V6.85795H5.89111V2.90281L0.784057 8L0 7.21635L5.11902 2.1072H1.12949Z\"></path></svg><span><span><span> reported that the exercise-induced hormone irisin curbs amyloid-β buildup by promoting secretion of astrocyte-derived </span>neprilysin. These findings may help explain the </span>neuroprotection by irisin and exercise in Alzheimer’s disease.</span></p>","PeriodicalId":23301,"journal":{"name":"Trends in Endocrinology & Metabolism","volume":"33 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2023-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Trends in Endocrinology & Metabolism","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1016/j.tem.2023.11.006","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Mounting evidence suggests that physical exercise protects the brain against neurodegenerative disease. In a recent paper in Neuron, Kim et al. reported that the exercise-induced hormone irisin curbs amyloid-β buildup by promoting secretion of astrocyte-derived neprilysin. These findings may help explain the neuroprotection by irisin and exercise in Alzheimer’s disease.
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