Effectiveness of Polyphenolic Acid Derived from Salvia miltiorrhiza on Injection Combined with Systematic Rehabilitation Nursing for Patients with Ischemic Stroke

Abstract

Ischemic stroke, a prevalent cerebral circulation disorder, often leads to profound physical and cognitive impairments, necessitating effective rehabilitation strategies. This study encompassed 110 diagnosed ischemic stroke patients treated at our neurology department from August 2019 to December 2021. Patients were randomly allocated into control and observation groups. The former received standard treatment and nursing care, while the latter underwent a combined regimen of salvianolic acids and systematic rehabilitation. Cell culture experiments exhibited heightened cell viability and reduced LDH secretion in the salvianolic acid-treated oxygen-glucose deprivation/reperfusion (OGD/R) injury model. Immunoblotting revealed elevated TGF-β1 protein expression in salvianolic acid-treated cells compared to controls. The observation group demonstrated lower NIHSS scores and improved emotional state relative to the conventional group. Moreover, the observation group exhibited significantly enhanced Barthel Index, cognitive function, and self-efficacy scores (P <0.05). These findings suggest a positive impact of the intervention on these parameters. In ischemic stroke patients, Salvia miltiorrhiza Bunge, a natural herbal remedy rich in salvianolic acids, exerts therapeutic effects through multiple pathways. The amalgamation of Salvia miltiorrhiza polyphenolic acid injection and systematic rehabilitation presents a favorable prospect for enhancing neurological recuperation, self-care capacity, self-efficacy, and patient convalescence. Therefore, Danggui injections hold potential as a clinical intervention for ischemic stroke management.