Pre-treatment inflammatory and immune system parameters predicting cervical cancer metastasis

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2023-12-01 DOI:10.4274/tjod.galenos.2023.80912

Mirah Avisha, N. Pelupessy, Abdul Rahman, Syahrul Rauf, Nur Rakhmah, Firdaus Hamid

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引用次数: 0

Abstract

Objective: This study aimed to evaluate the relationship between mannose-binding lectin-associated serine protease-2 as an immune system parameter and neutrophil lymphocyte ratio (NLR) as an inflammatory parameter to predict cervical cancer metastasis. Materials and Methods: This cross-sectional study included 70 patients diagnosed with cervical cancer between January 2022 and February 2023 at Dr. Wahidin Sudirohusodo Hospital, Hasanuddin University Hospital, and Ibnu Sina Hospital, Makassar, Indonesia. Blood samples taken before therapy as well as clinical and histological data were gathered and examined. MASP-2 levels and NLR were measured by ELISA and flow cytometry respectively. Results: The median age of the patients was 46 years (range, 24-72 years), with the majority of patients aged between 41 and 52 years. Statistical analysis showed that MASP-2 was associated with cervical cancer stage (p≤0.000), organ metastasis (p=0.011), and lymphovascular invasion (p=0.036). In addition, NLR was associated with cervical cancer stage (p=0.004), histopathology type (p=0.031), tumor size (p=0.019), and organ metastasis (p=0.013). Conclusion: Pretreatment with MASP-2 as an immune system parameter and NLR as an inflammatory parameter is associated with cervical cancer metastasis. The NLR indicator can be applied in clinical practice because it is simple and reasonably priced.

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预测宫颈癌转移的治疗前炎症和免疫系统参数

目的:探讨甘露糖结合凝集素相关丝氨酸蛋白酶-2与中性粒细胞淋巴细胞比值(NLR)在宫颈癌转移预测中的关系。材料和方法:本横断面研究纳入了印度尼西亚望加锡Wahidin Sudirohusodo医生医院、Hasanuddin大学医院和Ibnu Sina医院在2022年1月至2023年2月期间诊断为宫颈癌的70例患者。收集并检查治疗前采集的血液样本以及临床和组织学数据。ELISA法和流式细胞术分别检测MASP-2和NLR水平。结果:患者年龄中位数为46岁(范围24 ~ 72岁)，年龄以41 ~ 52岁居多。统计分析表明，MASP-2与宫颈癌分期(p≤0.000)、器官转移(p=0.011)、淋巴血管浸润(p=0.036)相关。此外，NLR与宫颈癌分期(p=0.004)、组织病理类型(p=0.031)、肿瘤大小(p=0.019)和器官转移(p=0.013)相关。结论:以MASP-2为免疫系统参数、NLR为炎症参数的预处理与宫颈癌转移有关。NLR指标简单、价格合理，可应用于临床。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.