REPARATIVE EFFECT OF MELATONIN ON THE MANDIBULAR ALVEOLAR BONE AND GINGIVA OF RATS WITH INDUCED PERIODONTITIS

Abstract

BACKGROUND: Periodontitis is a chronic inflammatory disease marked by intricate interactions between periodonto-pathogenic bacteria and the host’s immunity. It has a complicated etiology including bacterial colonization, excessive inflammation, and increased oxidative stress. Due to its antioxidant properties, stimulation of fibroblast proliferation, anti-inflammatory capacity, and bone remodeling capability; melatonin can contribute to ameliorating chronic conditions and can have potential dental applications such as in periodontal disease. AIM