BIOLOGICAL EFFECT OF HESPERIDIN ADMINISTRATION ON ALVEOLAR BONE STRUCTURE IN INDUCED DIABETIC RATS

Abstract

BACKGROUND: Diabetes mellitus (DM) is one of the most common endocrine disorders. It is associated with an elevation in blood glucose levels. Oxidative stress caused by hyperglycemia is central to the occurrence of diabetic complications such as retinopathy, nephropathy and diabetic osteopenia. Alveolar Bone forms the primary support structure of teeth. It’s affected majorly by diabetic osteopenia. Some antidiabetic drugs may also increase the risk of diabetic fractures. Hesperidin is an active flavanone isolated from citrus fruits . OBJECTIVES: The aim of the current study is to evaluate the effect of Hesperidin administration on alveolar bone structure in rats with Streptozotocin-induced diabetes. MATERIALS AND METHODS: Eighteen adult male albino rats will be randomly divided into 3 equal groups: Group I (Control group). Group II (DM group): Rats will be administered Streptozotocin (STZ) to induce DM. Group III (Hesperidin group): Rats with STZ–induced DM will be given Hesperidin via gastric gavage. Rats will be euthanized after 6 weeks. Mandibles will be dissected and prepared for histological evaluation by light and scanning electron microscope. Percentages of Calcium and Phosphorus will be analyzed using EDX . RESULTS: Control group showed normal histological features of the alveolar bone. The diabetic group revealed an irregular outline with severe destruction while the Hesperidin group showed almost normal restoration of the structure of alveolar bone . CONCLUSION: Hesperidin exerted a protective effect on alveolar bone osteoporosis in diabetic rats .