Distribution of Genetic Polymorphisms of the Agt M235t Gene in Hypertension Patients Taking Angiotensin-Converting Enzyme Inhibitor (ACEi) Drugs in Indonesia

Andi Thafida Khalisa, W. Widyati, S. Tuba
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Abstract

The condition of high blood pressure is characterized by a systolic pressure (TDS) ≤140 mmHg and a diastolic pressure (TDD) ≥ 90 mmHG. The M235T gene polymorphism inside the AGT gene has the potential to serve as a biomarker for the early identification and detection of hypertensive disease. The presence of the TT genotype and the T allele in the AGT M235T gene is associated with an increased susceptibility to hypertension. Furthermore, the study revealed a notable disparity in the occurrence of the AGTM235T variant (rs699) between individuals with hypertension and the control group. The objective of the study is to see the distribution of genetic polymorphism of AGT M235T gene in hypertensive patients taking Angiotensin-Converting Enzyme Inhibitor (ACEi) drugs. This study used the Narrative Review Method with a comprehensive systematic review of articles that have been published from 2013 to 2023 in English using the MEDLINE (PubMed), Google Scholar, and Cochrane Library databases. The AGT M235T polymorphism has been found to have a significant association with the use of ACEi medications in individuals diagnosed with hypertension, as indicated by several investigations. This study exhibits certain limitations and needs additional prospective investigations to corroborate the findings. In some studies, AGT M235T polymorphism in hypertension patients has a strong correlation with ACEi drugs.
印度尼西亚服用血管紧张素转换酶抑制剂 (ACEi) 药物的高血压患者的 Agt M235t 基因多态性分布情况
高血压的特点是收缩压(TDS)≤140 mmHg,舒张压(TDD)≥90 mmHg。AGT基因内的M235T基因多态性有可能作为高血压疾病早期识别和检测的生物标志物。AGT M235T基因中TT基因型和T等位基因的存在与高血压易感性增加有关。此外,该研究还揭示了高血压个体与对照组之间AGTM235T变异(rs699)的发生率存在显著差异。本研究的目的是观察AGT M235T基因在服用血管紧张素转换酶抑制剂(ACEi)的高血压患者中的遗传多态性分布。本研究采用叙述性综述法,对2013年至2023年在MEDLINE (PubMed)、Google Scholar和Cochrane Library数据库中发表的英文文章进行了全面系统的综述。一些研究表明,AGT M235T多态性与诊断为高血压的个体使用ACEi药物有显著关联。本研究显示出一定的局限性,需要进一步的前瞻性调查来证实研究结果。在一些研究中,高血压患者AGT M235T多态性与ACEi药物有很强的相关性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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