A Brief Review on Manipulation of Essential Metal Ions as Nanomedicine for Cancer Therapy

IF 4 Q2 ENGINEERING, BIOMEDICAL

Advanced Nanobiomed Research Pub Date : 2023-12-03 DOI:10.1002/anbr.202300069

Lin Weng, Xin Chen

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Abstract

In this review, the latest progress in essential metal-ion-based nanomedicines for tumor therapy is summarized, existing challenges are addressed, and possible directions are proposed for such therapeutic strategies. Essential metal ions are critical for the metabolic activity of organisms. Their abnormal spatial and temporal distribution in biological systems, particularly inside the cell, disrupts biochemical processes and leads to irreversible physicochemical damage to cells. Thus, they can function as the foundation of targeted cancer therapies for tumor inhibition and eradication. Over the last decade, numerous essential metal-ion-based cancer therapies have been developed to fight a wide spectrum of cancers with improved efficiency and minor drug resistance. Triggering biocatalysis, affecting protein metabolism, interfering with signal transduction, damaging DNA, and initiating biomineralization are the main mechanisms underlying these therapies. In this study, it is aimed to provide readers with general implications for future research for an increased interest in future clinical applications of these advanced cancer therapies.

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将基本金属离子作为纳米药物用于癌症治疗的简要回顾

本文综述了金属离子基纳米药物在肿瘤治疗中的最新进展，指出了存在的挑战，并提出了可能的发展方向。必需金属离子对生物体的代谢活动至关重要。它们在生物系统中的异常时空分布，特别是在细胞内，破坏生物化学过程，导致细胞不可逆转的物理化学损伤。因此，它们可以作为肿瘤抑制和根除的靶向癌症治疗的基础。在过去的十年中，许多以金属离子为基础的癌症治疗方法已经被开发出来，以提高效率和减少耐药性来对抗广泛的癌症。触发生物催化、影响蛋白质代谢、干扰信号转导、损伤DNA和启动生物矿化是这些治疗的主要机制。在这项研究中，它旨在为读者提供对这些先进癌症治疗的未来临床应用增加兴趣的未来研究的一般含义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Advanced Nanobiomed Research nanomedicine, bioengineering and biomaterials-

CiteScore

5.00

自引率

5.90%

发文量

审稿时长

21 weeks

期刊介绍： Advanced NanoBiomed Research will provide an Open Access home for cutting-edge nanomedicine, bioengineering and biomaterials research aimed at improving human health. The journal will capture a broad spectrum of research from increasingly multi- and interdisciplinary fields of the traditional areas of biomedicine, bioengineering and health-related materials science as well as precision and personalized medicine, drug delivery, and artificial intelligence-driven health science. The scope of Advanced NanoBiomed Research will cover the following key subject areas: ▪ Nanomedicine and nanotechnology, with applications in drug and gene delivery, diagnostics, theranostics, photothermal and photodynamic therapy and multimodal imaging. ▪ Biomaterials, including hydrogels, 2D materials, biopolymers, composites, biodegradable materials, biohybrids and biomimetics (such as artificial cells, exosomes and extracellular vesicles), as well as all organic and inorganic materials for biomedical applications. ▪ Biointerfaces, such as anti-microbial surfaces and coatings, as well as interfaces for cellular engineering, immunoengineering and 3D cell culture. ▪ Biofabrication including (bio)inks and technologies, towards generation of functional tissues and organs. ▪ Tissue engineering and regenerative medicine, including scaffolds and scaffold-free approaches, for bone, ligament, muscle, skin, neural, cardiac tissue engineering and tissue vascularization. ▪ Devices for healthcare applications, disease modelling and treatment, such as diagnostics, lab-on-a-chip, organs-on-a-chip, bioMEMS, bioelectronics, wearables, actuators, soft robotics, and intelligent drug delivery systems. with a strong focus on applications of these fields, from bench-to-bedside, for treatment of all diseases and disorders, such as infectious, autoimmune, cardiovascular and metabolic diseases, neurological disorders and cancer; including pharmacology and toxicology studies.