Impaired polymorphonuclear neutrophil functions in diabetics

IMC Journal of Medical Science Pub Date : 2023-12-05 DOI:10.55010/imcjms.18.008

Tanzinah Nasrin, Nurun Nahar Faizunnesa, Sraboni Mazumder

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Abstract

Background and objectives: Polymorphonuclear neutrophils (PMN) are the first line of host resistance against infections. Diabetics are prone to both bacterial and fungal infections. The present study evaluated the phagocytic and killing activity of PMN in diabetics. Material and methods: Females aged 30 to 50 years with and without diabetes mellitus were enrolled. Functions of PMN were assessed by determining the phagocytic rate, phagocytic index and killing of C. albicans by PMN. Results: A total of 36 diabetic patients and 15 age matched non-diabetic healthy individuals were enrolled. Phagocytosis and killing of C. albicans by PMN were significantly (p<0.05) lower in patients with diabetes mellitus compared to non-diabetic healthy individuals (86.5±14.6 vs. 94.5±4.2; 56.7±23.8 vs. 81.5±24.2). Conclusion: Phagocytic and killing functions of PMN were significantly reduced in patients with diabetes mellitus. IMC J Med Sci. 2024; 18(1):008. DOI: https://doi.org/10.55010/imcjms.18.008 *Correspondence:Tanzinah Nasrin, Microbiologist, Quality Control Laboratory, Department of Fisheries, Ministry of Fisheries and Livestock, Dhaka, Bangladesh. Email: tanzinahn8@gmail.com

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糖尿病患者的多形核中性粒细胞功能受损

背景与目的:多形核中性粒细胞(PMN)是宿主抗感染的第一线。糖尿病患者容易受到细菌和真菌感染。本研究评价了PMN在糖尿病患者体内的吞噬和杀伤活性。材料与方法:年龄30 ~ 50岁，伴有或不伴有糖尿病的女性。通过测定PMN的吞噬率、吞噬指数和对白色念珠菌的杀伤作用来评价PMN的功能。结果:共纳入36例糖尿病患者和15例年龄匹配的非糖尿病健康人。糖尿病患者PMN对白色念珠菌的吞噬和杀伤能力显著低于非糖尿病健康人(86.5±14.6∶94.5±4.2;56.7±23.8 vs. 81.5±24.2)。结论:糖尿病患者PMN的吞噬和杀伤功能明显降低。中华医学会医学杂志。2024;18(1): 008。DOI: https://doi.org/10.55010/imcjms.18.008*Correspondence:Tanzinah纳斯林，微生物学家，质量控制实验室，渔业和畜牧业部，孟加拉国达卡。电子邮件:tanzinahn8@gmail.com

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IMC Journal of Medical Science

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审稿时长

6 weeks