Bisphenol A (BPA) and Cardiovascular or Cardiometabolic Diseases

IF 6.8 Q1 TOXICOLOGY

Journal of Xenobiotics Pub Date : 2023-12-05 DOI:10.3390/jox13040049

Jeong-Hun Kang, Daisuke Asai, R. Toita

引用次数: 0

Abstract

Bisphenol A (BPA; 4,4′-isopropylidenediphenol) is a well-known endocrine disruptor. Most human exposure to BPA occurs through the consumption of BPA-contaminated foods. Cardiovascular or cardiometabolic diseases such as diabetes, obesity, hypertension, acute kidney disease, chronic kidney disease, and heart failure are the leading causes of death worldwide. Positive associations have been reported between blood or urinary BPA levels and cardiovascular or cardiometabolic diseases. BPA also induces disorders or dysfunctions in the tissues associated with these diseases through various cell signaling pathways. This review highlights the literature elucidating the relationship between BPA and various cardiovascular or cardiometabolic diseases and the potential mechanisms underlying BPA-mediated disorders or dysfunctions in tissues such as blood vessels, skeletal muscle, adipose tissue, liver, pancreas, kidney, and heart that are associated with these diseases.

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双酚 A (BPA) 与心血管疾病或心脏代谢疾病

双酚A (BPA;4,4 ' -异丙基二酚)是一种众所周知的内分泌干扰物。大多数人类接触双酚a是通过食用受双酚a污染的食物。心血管或心脏代谢疾病，如糖尿病、肥胖、高血压、急性肾脏疾病、慢性肾脏疾病和心力衰竭，是全世界死亡的主要原因。据报道，血液或尿液双酚a水平与心血管或心血管代谢疾病呈正相关。BPA还通过各种细胞信号通路在与这些疾病相关的组织中诱导失调或功能障碍。本文综述了阐明BPA与各种心血管或心血管代谢疾病之间关系的文献，以及BPA介导的与这些疾病相关的组织(如血管、骨骼肌、脂肪组织、肝脏、胰腺、肾脏和心脏)疾病或功能障碍的潜在机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Xenobiotics TOXICOLOGY-

CiteScore

5.30

自引率

1.70%

发文量

审稿时长

10 weeks

期刊介绍： The Journal of Xenobiotics publishes original studies concerning the beneficial (pharmacology) and detrimental effects (toxicology) of xenobiotics in all organisms. A xenobiotic (“stranger to life”) is defined as a chemical that is not usually found at significant concentrations or expected to reside for long periods in organisms. In addition to man-made chemicals, natural products could also be of interest if they have potent biological properties, special medicinal properties or that a given organism is at risk of exposure in the environment. Topics dealing with abiotic- and biotic-based transformations in various media (xenobiochemistry) and environmental toxicology are also of interest. Areas of interests include the identification of key physical and chemical properties of molecules that predict biological effects and persistence in the environment; the molecular mode of action of xenobiotics; biochemical and physiological interactions leading to change in organism health; pathophysiological interactions of natural and synthetic chemicals; development of biochemical indicators including new “-omics” approaches to identify biomarkers of exposure or effects for xenobiotics.