The functions of EF-hand proteins from host and zoonotic pathogens

IF 2.6 4区医学 Q3 IMMUNOLOGY

Microbes and Infection Pub Date : 2025-01-01 DOI:10.1016/j.micinf.2023.105276

Wei Zuo , Mingxing Tian , Jingjing Qi , Guangdong Zhang , Jiangang Hu , Shaohui Wang , Yanqing Bao

引用次数: 0

Abstract

EF-hand proteins not only regulate biological processes, but also influence immunity and infection. In this review, we summarize EF-hand proteins' functions in host and zoonotic pathogens, with details in structures, Ca²⁺ affinity, downstream targets and functional mechanisms. Studies entitled as EF-hand-related but with less solid features were also discussed. We believe it could raise cautions and facilitate proper research strategy for researchers.

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宿主和人畜共患病原体的 EF-手蛋白的功能

EF 手蛋白不仅能调节生物过程，还能影响免疫和感染。在这篇综述中，我们总结了 EF-手蛋白在宿主和人畜共患病原体中的功能，详细介绍了其结构、Ca2+ 亲和力、下游靶标和功能机制。此外，还讨论了被称为与 EF-手相关但特征不那么明确的研究。我们相信，它能为研究人员提出警示，帮助他们制定正确的研究策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Microbes and Infection 医学-病毒学

CiteScore

12.60

自引率

1.70%

发文量

审稿时长

40 days

期刊介绍： Microbes and Infection publishes 10 peer-reviewed issues per year in all fields of infection and immunity, covering the different levels of host-microbe interactions, and in particular: the molecular biology and cell biology of the crosstalk between hosts (human and model organisms) and microbes (viruses, bacteria, parasites and fungi), including molecular virulence and evasion mechanisms. the immune response to infection, including pathogenesis and host susceptibility. emerging human infectious diseases. systems immunology. molecular epidemiology/genetics of host pathogen interactions. microbiota and host "interactions". vaccine development, including novel strategies and adjuvants. Clinical studies, accounts of clinical trials and biomarker studies in infectious diseases are within the scope of the journal. Microbes and Infection publishes articles on human pathogens or pathogens of model systems. However, articles on other microbes can be published if they contribute to our understanding of basic mechanisms of host-pathogen interactions. Purely descriptive and preliminary studies are discouraged.