Blurred lines: Crossing the boundaries between the chemical exposome and the metabolome

IF 6.9 2区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Cristina Balcells , Yitao Xu , Rubén Gil-Solsona , Léa Maitre , Pablo Gago-Ferrero , Hector C. Keun
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Abstract

The aetiology of every human disease lies in a combination of genetic and environmental factors, each contributing in varying proportions. While genomics investigates the former, a comparable holistic paradigm was proposed for environmental exposures in 2005, marking the onset of exposome research. Since then, the exposome definition has broadened to include a wide array of physical, chemical, and psychosocial factors that interact with the human body and potentially alter the epigenome, the transcriptome, the proteome, and the metabolome. The chemical exposome, deeply intertwined with the metabolome, includes all small molecules originating from diet as well as pharmaceuticals, personal care and consumer products, or pollutants in air and water. The set of techniques to interrogate these exposures, primarily mass spectrometry and nuclear magnetic resonance spectroscopy, are also extensively used in metabolomics. Recent advances in untargeted metabolomics using high resolution mass spectrometry have paved the way for the development of methods able to provide in depth characterisation of both the internal chemical exposome and the endogenous metabolome simultaneously. Herein we review the available tools, databases, and workflows currently available for such work, and discuss how these can bridge the gap between the study of the metabolome and the exposome.

Abstract Image

Abstract Image

界限模糊:跨越化学暴露组和代谢组之间的界限
人类每种疾病的病因都是遗传因素和环境因素的结合,两者的比例各不相同。基因组学研究的是前者,而环境暴露则是在 2005 年提出的一个类似的整体范式,标志着暴露组研究的开始。从那时起,暴露组的定义已扩大到包括一系列与人体相互作用并可能改变表观基因组、转录组、蛋白质组和代谢组的物理、化学和社会心理因素。化学暴露组与代谢组密切相关,包括来自饮食、药品、个人护理和消费品或空气和水中污染物的所有小分子。质谱法和核磁共振光谱法等一整套用于检测这些暴露的技术也被广泛应用于代谢组学研究。利用高分辨率质谱技术进行非靶向代谢组学研究的最新进展为开发能够同时深入分析内部化学暴露组和内源性代谢组的方法铺平了道路。在此,我们回顾了目前可用于此类工作的可用工具、数据库和工作流程,并讨论了这些工具、数据库和工作流程如何能弥合代谢组和暴露组研究之间的差距。
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来源期刊
Current Opinion in Chemical Biology
Current Opinion in Chemical Biology 生物-生化与分子生物学
CiteScore
13.30
自引率
1.30%
发文量
113
审稿时长
74 days
期刊介绍: COCHBI (Current Opinion in Chemical Biology) is a systematic review journal designed to offer specialists a unique and educational platform. Its goal is to help professionals stay informed about the growing volume of information in the field of Chemical Biology through systematic reviews.
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