Current Trends in the Application of Stem Cells and Their Derivatives in Animal Sperm Cryopreservation

IF 1.1 Q4 CELL BIOLOGY

Biochemistry (Moscow), Supplement Series A: Membrane and Cell Biology Pub Date : 2023-12-10 DOI:10.1134/S1990747823050112

M. A. Tambovsky, A. M. Aimaletdinov, E. Yu. Zakirova

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Abstract

Sperm cryopreservation is an important part of preserving the germ cells of various organisms. However, when gametes are frozen, various damage often occur, which have a significant impact in artificial insemination. After thawing, spermatozoa usually have ultrastructural, biochemical, and functional changes such as damage of cell membrane and chromatin and oxidative stress. Since spermatozoa have a limited capacity for biosynthetic activity, they have a low capacity for regeneration. The current trend is to improve sperm cryopreservation using natural extracellular vesicles and stem cells. Extracellular vesicles and stem cells have potential regenerative effects because they contain various bioactive molecules to affect sperm repair. The present review focuses on current strategies to improve sperm health after cryopreservation. In particular, this review describes the results of studies on the use of extracellular vesicles and stem cells as cryoprotectants during sperm freezing and thawing.

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干细胞及其衍生物在动物精子冷冻保存中的应用趋势

摘要精子冷冻保存是保存各种生物生殖细胞的重要环节。然而，配子在冷冻过程中往往会出现各种损伤，这对人工授精有很大影响。解冻后的精子通常会出现超微结构、生物化学和功能上的变化，如细胞膜和染色质受损、氧化应激等。由于精子的生物合成能力有限，其再生能力较低。目前的趋势是利用天然细胞外囊泡和干细胞改进精子冷冻保存。细胞外囊泡和干细胞具有潜在的再生作用，因为它们含有各种生物活性分子，可影响精子的修复。本综述重点介绍了目前改善冷冻保存后精子健康状况的策略。本综述特别介绍了在精子冷冻和解冻过程中使用细胞外囊泡和干细胞作为冷冻保护剂的研究结果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biochemistry (Moscow), Supplement Series A: Membrane and Cell Biology CELL BIOLOGY-

CiteScore

1.40

自引率

0.00%

发文量

期刊介绍： Biochemistry (Moscow), Supplement Series A: Membrane and Cell Biology is an international peer reviewed journal that publishes original articles on physical, chemical, and molecular mechanisms that underlie basic properties of biological membranes and mediate membrane-related cellular functions. The primary topics of the journal are membrane structure, mechanisms of membrane transport, bioenergetics and photobiology, intracellular signaling as well as membrane aspects of cell biology, immunology, and medicine. The journal is multidisciplinary and gives preference to those articles that employ a variety of experimental approaches, basically in biophysics but also in biochemistry, cytology, and molecular biology. The journal publishes articles that strive for unveiling membrane and cellular functions through innovative theoretical models and computer simulations.