Prevalence of xylazine among people who inject drugs seeking medical care at a syringe services program clinic: Miami, Florida, 2023

Drug and alcohol dependence reports Pub Date : 2023-12-01 DOI:10.1016/j.dadr.2023.100209

Maia H. Hauschild , Peyton V. Warp , Hansel E. Tookes , Ella Yakir , Bharat Malhotra , Subul Malik , Cyrus Owens , Edward Suarez Jr , David P. Serota , Tyler S. Bartholomew

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Abstract

Background

We aimed to report the preliminary xylazine prevalence among people who inject drugs (PWID) treated at a student-run free clinic in Miami, FL, USA and to identify characteristics associated with screening positive for xylazine.

Methods

A retrospective chart review of 59 patients presenting to a syringe services program (SSP) clinic in was conducted between April 27th and August 17th, 2023. We measured presence of xylazine with rapid visual immunoassay strips on patient urine samples.

Results

Xylazine was present in 55.9 % (33/59) of urine samples including 2 without detected opioids. Xylazine presence was significantly associated with unsheltered homelessness (p = 0.018), presence of wound(s) (p = 0.008), and testing positive for hepatitis C antibody (p = 0.014), fentanyl (p = 0.005) and MDMA (p = 0.002).

Conclusions

A high prevalence of xylazine in the Southeastern United States furthers evidence of the geographical spread of xylazine and rapidly evolving illicit drug supply. Widespread xylazine screening is urgently needed to inform people who inject drugs and to studyinterventions to minimize harms associated with xylazine.

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在注射器服务计划诊所就医的注射吸毒者中，异丙嗪的流行率：佛罗里达州迈阿密，2023 年

背景我们旨在报告在美国佛罗里达州迈阿密市一家由学生开办的免费诊所接受治疗的注射吸毒者（PWID）中甲苄嗪的初步流行率，并确定与甲苄嗪筛查阳性相关的特征。结果 55.9%（33/59）的尿样中发现了异丙嗪，其中包括 2 份未检测到阿片类药物的尿样。结果55.9%（33/59）的尿样中含有异丙嗪，其中2例未检测到阿片类药物。异丙嗪的存在与无家可归（p = 0.018）、有伤口（p = 0.008）以及丙型肝炎抗体（p = 0.014）、芬太尼（p = 0.005）和亚甲二氧基甲基安非他明（p = 0.002）检测呈阳性明显相关。目前急需广泛开展二甲肼筛查，以告知注射吸毒者并研究如何采取干预措施将二甲肼的危害降至最低。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Drug and alcohol dependence reports Psychiatry and Mental Health

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审稿时长

100 days