Recent advances in single-cell engineered live biotherapeutic products research for skin repair and disease treatment

IF 7.8 1区生物学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

npj Biofilms and Microbiomes Pub Date : 2023-12-08 DOI:10.1038/s41522-023-00463-8

Muhamad Aidilfitri Mohamad Roslan, Mohd Norfikri Omar, Nur Azlina Mohd Sharif, Nurul Hanun Ahmad Raston, Mohd Hafiz Arzmi, Hui-Min Neoh, Ahmad Bazli Ramzi

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Abstract

The human microbiome has emerged as a key player in maintaining skin health, and dysbiosis has been linked to various skin disorders. Amidst growing concerns regarding the side effects of antibiotic treatments, the potential of live biotherapeutic products (LBPs) in restoring a healthy microbiome has garnered significant attention. This review aims to evaluate the current state of the art of the genetically or metabolically engineered LBPs, termed single-cell engineered LBPs (eLBPs), for skin repair and disease treatment. While some studies demonstrate promising outcomes, the translation of eLBPs into clinical applications remains a significant hurdle. Substantial concerns arise regarding the practical implementation and scalability of eLBPs, despite the evident potential they hold in targeting specific cells and delivering therapeutic agents. This review underscores the need for further research, robust clinical trials, and the exploration of current advances in eLBP-based bioengineered bacterial chassis and new outlooks to substantiate the viability and effectiveness of eLBPs as a transformative approach in skin repair and disease intervention.

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用于皮肤修复和疾病治疗的单细胞工程活生物治疗产品研究的最新进展

人类微生物群已成为维持皮肤健康的关键因素，而菌群失调则与各种皮肤疾病有关。随着人们对抗生素治疗副作用的担忧与日俱增，活生物治疗产品（LBPs）在恢复健康微生物群方面的潜力引起了人们的极大关注。本综述旨在评估用于皮肤修复和疾病治疗的基因或代谢工程 LBPs（称为单细胞工程 LBPs（eLBPs））的技术现状。虽然一些研究显示了良好的结果，但将 eLBPs 转化为临床应用仍是一个重大障碍。尽管 eLBPs 在靶向特定细胞和递送治疗药物方面具有明显的潜力，但在实际应用和可扩展性方面仍存在很大问题。这篇综述强调了进一步研究、稳健的临床试验以及探索基于 eLBP 的生物工程细菌底盘的当前进展和新前景的必要性，以证实 eLBP 作为皮肤修复和疾病干预的变革性方法的可行性和有效性。

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来源期刊

npj Biofilms and Microbiomes Immunology and Microbiology-Microbiology

CiteScore

12.10

自引率

3.30%

发文量

审稿时长

9 weeks

期刊介绍： npj Biofilms and Microbiomes is a comprehensive platform that promotes research on biofilms and microbiomes across various scientific disciplines. The journal facilitates cross-disciplinary discussions to enhance our understanding of the biology, ecology, and communal functions of biofilms, populations, and communities. It also focuses on applications in the medical, environmental, and engineering domains. The scope of the journal encompasses all aspects of the field, ranging from cell-cell communication and single cell interactions to the microbiomes of humans, animals, plants, and natural and built environments. The journal also welcomes research on the virome, phageome, mycome, and fungome. It publishes both applied science and theoretical work. As an open access and interdisciplinary journal, its primary goal is to publish significant scientific advancements in microbial biofilms and microbiomes. The journal enables discussions that span multiple disciplines and contributes to our understanding of the social behavior of microbial biofilm populations and communities, and their impact on life, human health, and the environment.

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