Serum neuregulin 1 in relation to ventricular function and subclinical atherosclerosis in type 2 diabetes patients

IF 1.8 4区医学 Q4 ENDOCRINOLOGY & METABOLISM

Endocrinologia Diabetes Y Nutricion Pub Date : 2023-12-01 DOI:10.1016/j.endien.2023.11.010

Aya Saad Eldin , Olfat Fawzy , Eman Mahmoud , Ola H. Abd Elaziz , Alshimaa Ezzat A. Enayet , Emad Gamil Khidr

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引用次数: 0

Abstract

Background and aims

Neuregulin 1 (NRG-1) is one of the members of the epidermal growth factors proteins. The present study provides novel insights into the relationship between serum levels of NRG-1 and insulin resistance, subclinical atherosclerosis and cardiac dysfunction that occur in type 2 diabetes (T2D).

Methods

The study included 50 patients with T2D and 40 healthy age- and gender-matched controls. Serum NRG-1 was measured using ELISA. Glycemic parameters, lipid profile and insulin resistance were assessed. Trans-thoracic echocardiography and carotid intima media thickness (CIMT) were studied for all study subjects.

Results

T2D patients had significantly lower serum NRG-1 levels than controls. Serum NRG-1 was negatively correlated with age, fasting blood glucose, HbA1c, insulin resistance, blood urea, serum creatinine and LDL-C, and positively correlated with HDL-C, eGFR and CIMT. Regarding echocardiographic variables, serum NRG-1 was found to correlate positively with left ventricular global longitudinal strain and negatively with E/E_a ratio. NRG-1 was found to predict subclinical atherosclerosis in type 2 diabetes patients at a cut-off value < 108.5 pg/ml with 78% sensitivity and 80% specificity.

Conclusions

A robust relationship was found between serum NRG-1 levels and hyperglycemia, insulin resistance, subclinical atherosclerosis, and cardiac dysfunction in patients with type 2 diabetes. These results shed light on a possible role of NRG-1 as a potential noninvasive biomarker for detection of cardiometabolic risk in T2D.

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血清神经胶质蛋白 1 与 2 型糖尿病患者心室功能和亚临床动脉粥样硬化的关系

背景和目的神经胶质蛋白 1（NRG-1）是表皮生长因子蛋白的成员之一。本研究就血清中 NRG-1 的水平与 2 型糖尿病（T2D）患者胰岛素抵抗、亚临床动脉粥样硬化和心脏功能障碍之间的关系提供了新的见解。采用酶联免疫吸附法测定血清 NRG-1。对血糖参数、血脂状况和胰岛素抵抗进行了评估。对所有研究对象进行了经胸超声心动图和颈动脉内膜厚度（CIMT）研究。血清 NRG-1 与年龄、空腹血糖、HbA1c、胰岛素抵抗、血尿素、血清肌酐和 LDL-C 呈负相关，与 HDL-C、eGFR 和 CIMT 呈正相关。在超声心动图变量方面，发现血清 NRG-1 与左心室整体纵向应变呈正相关，与 E/Ea 比值呈负相关。结论发现血清 NRG-1 水平与 2 型糖尿病患者的高血糖、胰岛素抵抗、亚临床动脉粥样硬化和心脏功能障碍之间存在密切关系。这些结果表明，NRG-1 可能是检测 2 型糖尿病患者心脏代谢风险的潜在非侵入性生物标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Endocrinologia Diabetes Y Nutricion Multiple-

CiteScore

2.10

自引率

10.50%

发文量

期刊介绍： Endocrinología, Diabetes y Nutrición is the official journal of the Spanish Society of Endocrinology and Nutrition (Sociedad Española de Endocrinología y Nutrición, SEEN) and the Spanish Society of Diabetes (Sociedad Española de Diabetes, SED), and was founded in 1954. The aim of the journal is to improve knowledge and be a useful tool in practice for clinical and laboratory specialists, trainee physicians, researchers, and nurses interested in endocrinology, diabetes, nutrition and related disciplines. It is an international journal published in Spanish (print and online) and English (online), covering different fields of endocrinology and metabolism, including diabetes, obesity, and nutrition disorders, as well as the most relevant research produced mainly in Spanish language territories. The quality of the contents is ensured by a prestigious national and international board, and by a selected panel of specialists involved in a rigorous peer review. The result is that only manuscripts containing high quality research and with utmost interest for clinicians and professionals related in the field are published. The Journal publishes Original clinical and research articles, Reviews, Special articles, Clinical Guidelines, Position Statements from both societies and Letters to the editor. Endocrinología, Diabetes y Nutrición can be found at Science Citation Index Expanded, Medline/PubMed and SCOPUS.