Unraveling the lost balance: Adrenergic dysfunction in cancer cachexia

IF 3.2 4区医学 Q2 NEUROSCIENCES

Autonomic Neuroscience-Basic & Clinical Pub Date : 2023-12-06 DOI:10.1016/j.autneu.2023.103136

Parham Diba , Ariana L. Sattler , Tetiana Korzun , Beth A. Habecker , Daniel L. Marks

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引用次数: 0

Abstract

Cancer cachexia, characterized by muscle wasting and widespread inflammation, poses a significant challenge for patients with cancer, profoundly impacting both their quality of life and treatment management. However, existing treatment modalities remain very limited, accentuating the necessity for innovative therapeutic interventions. Many recent studies demonstrated that changes in autonomic balance is a key driver of cancer cachexia. This review consolidates research findings from investigations into autonomic dysfunction across cancer cachexia, spanning animal models and patient cohorts. Moreover, we explore therapeutic strategies involving adrenergic receptor modulation through receptor blockers and agonists. Mechanisms underlying adrenergic hyperactivity in cardiac and adipose tissues, influencing tissue remodeling, are also examined. Looking ahead, we present a perspective for future research that delves into autonomic dysregulation in cancer cachexia. This comprehensive review highlights the urgency of advancing research to unveil innovative avenues for combatting cancer cachexia and improving patient well-being.

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打破失去的平衡癌症恶病质中的肾上腺素能功能障碍

癌症恶病质以肌肉萎缩和广泛的炎症为特征，对癌症患者构成了巨大挑战，严重影响了他们的生活质量和治疗管理。然而，现有的治疗方法仍然非常有限，这就更加凸显了创新治疗干预措施的必要性。最近的许多研究表明，自律神经平衡的变化是癌症恶病质的主要驱动因素。本综述整合了对癌症恶病质中自律神经功能失调的研究成果，涉及动物模型和患者队列。此外，我们还探讨了通过受体阻滞剂和激动剂调节肾上腺素能受体的治疗策略。我们还研究了心脏和脂肪组织中肾上腺素能亢进影响组织重塑的机制。展望未来，我们提出了对癌症恶病质中自律神经失调的未来研究展望。这篇全面的综述强调了推进研究的紧迫性，以揭示抗击癌症恶病质和改善患者福祉的创新途径。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Autonomic Neuroscience-Basic & Clinical 医学-神经科学

CiteScore

5.80

自引率

7.40%

发文量

审稿时长

66 days

期刊介绍： This is an international journal with broad coverage of all aspects of the autonomic nervous system in man and animals. The main areas of interest include the innervation of blood vessels and viscera, autonomic ganglia, efferent and afferent autonomic pathways, and autonomic nuclei and pathways in the central nervous system. The Editors will consider papers that deal with any aspect of the autonomic nervous system, including structure, physiology, pharmacology, biochemistry, development, evolution, ageing, behavioural aspects, integrative role and influence on emotional and physical states of the body. Interdisciplinary studies will be encouraged. Studies dealing with human pathology will be also welcome.