N-vinylcaprolactam-based temperature and pH-sensitive graft hydrogels for controlled drug release of 5-FU: a comprehensive study on synthesis, characterization, and release kinetics

IF 2.8 4区工程技术 Q2 POLYMER SCIENCE

Macromolecular Research Pub Date : 2023-12-06 DOI:10.1007/s13233-023-00222-w

İ. K. Akbay, T. Özdemir

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引用次数: 0

Abstract

Stimuli-responsive polymers can be used for various purposes due to their amazing properties within the context of controlled release systems. In this study, the aim was to prepare hydrogels that are stimulus-responsive to temperature and pH and utilize them in drug release investigations. N-Vinyl caprolactam-based polymers were synthesized and optimized based on the swelling ratio data. Both temperature and pH sensitivity, along with their respective transition values, were determined. The best sample was selected based on 5-FU encapsulation efficiency. To enhance the swelling ratio and encapsulation values, different amounts of poly-(ethylene glycol) were added to improve water swelling ratio and 5-FU release properties. All obtained samples were characterized using water swelling ratio, SEM, FTIR, and DSC analyses. Additionally, the encapsulation and release of the 5-FU drug from the hydrogels were studied. According to the results, it was understood that it could release the 5-FU drug approximately 14% when below the transition temperature and pH value, and approximately 99% when above the transition temperature and pH value. The kinetics of the drug release were thoroughly examined. The results of thekinetic study revealed a drug release pattern consistent with Fick's law.

Graphical abstract

Synthesis and drug release route for the study

Abstract Image

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用于控制 5-FU 药物释放的 N-乙烯基己内酰胺基温度和 pH 值敏感接枝水凝胶：关于合成、表征和释放动力学的综合研究

刺激响应型聚合物在控释系统中具有惊人的特性，可用于多种用途。本研究旨在制备对温度和 pH 值具有刺激响应的水凝胶，并将其用于药物释放研究。根据溶胀比数据合成并优化了 N-乙烯基己内酰胺聚合物。确定了温度和 pH 敏感性及其各自的过渡值。根据 5-FU 的封装效率选出了最佳样品。为了提高溶胀率和封装值，添加了不同量的聚乙二醇，以改善水溶胀率和 5-FU 释放性能。所有获得的样品都通过水膨胀率、扫描电镜、傅立叶变换红外光谱和 DSC 分析进行了表征。此外，还研究了水凝胶中 5-FU 药物的封装和释放情况。结果表明，当低于转变温度和 pH 值时，水凝胶可释放约 14% 的 5-FU 药物，而当高于转变温度和 pH 值时，水凝胶可释放约 99% 的 5-FU 药物。对药物释放的动力学进行了深入研究。动力学研究结果表明，药物释放模式符合菲克定律。

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来源期刊

Macromolecular Research 工程技术-高分子科学

CiteScore

4.70

自引率

8.30%

发文量

100

审稿时长

1.3 months

期刊介绍： Original research on all aspects of polymer science, engineering and technology, including nanotechnology Presents original research articles on all aspects of polymer science, engineering and technology Coverage extends to such topics as nanotechnology, biotechnology and information technology The English-language journal of the Polymer Society of Korea Macromolecular Research is a scientific journal published monthly by the Polymer Society of Korea. Macromolecular Research publishes original researches on all aspects of polymer science, engineering, and technology as well as new emerging technologies using polymeric materials including nanotechnology, biotechnology, and information technology in forms of Articles, Communications, Notes, Reviews, and Feature articles.