{"title":"Post-Covid Syndrome: Pathophysiology of Systemic Dysregulations","authors":"O. A. Gomazkov","doi":"10.1134/s2079086423060087","DOIUrl":null,"url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Abstract</h3><p>The main processes that characterize the post-COVID syndrome are analyzed as a version of the “prolonged” pathology of acute COVID-19. Considering the variety of manifestations of post-covid pathology, the main blocks of systemic, cellular, and molecular dysregulations are distinguished. As the main reasons, the following are considered: the consequences of systemic and organ damage in the acute phase of COVID-19, the persistent activity of “hidden” pathogens, and the altered status of the patient’s protective immune systems. Postcoagulant pathology, as a multisystem syndrome, reflects disturbances in the main cellular and molecular regulatory systems: stochastic disorganization of immune responses, vascular endothelial dysfunction, cellular inflammation, imbalance of coagulation and antithrombosis systems, deviations in autoimmune processes, etc. These findings orient new cellular and biochemical targets for timely therapy. The varied nature of the symptoms suggests a selective use of therapeutic approaches.</p>","PeriodicalId":9047,"journal":{"name":"Biology Bulletin Reviews","volume":"34 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2023-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biology Bulletin Reviews","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1134/s2079086423060087","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
The main processes that characterize the post-COVID syndrome are analyzed as a version of the “prolonged” pathology of acute COVID-19. Considering the variety of manifestations of post-covid pathology, the main blocks of systemic, cellular, and molecular dysregulations are distinguished. As the main reasons, the following are considered: the consequences of systemic and organ damage in the acute phase of COVID-19, the persistent activity of “hidden” pathogens, and the altered status of the patient’s protective immune systems. Postcoagulant pathology, as a multisystem syndrome, reflects disturbances in the main cellular and molecular regulatory systems: stochastic disorganization of immune responses, vascular endothelial dysfunction, cellular inflammation, imbalance of coagulation and antithrombosis systems, deviations in autoimmune processes, etc. These findings orient new cellular and biochemical targets for timely therapy. The varied nature of the symptoms suggests a selective use of therapeutic approaches.
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