miR-379-3p inhibits fat grafting survival and angiogenesis by targeting SOCS1-mediated adipose inflammation

IF 2.3 4区生物学 Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Electronic Journal of Biotechnology Pub Date : 2023-11-23 DOI:10.1016/j.ejbt.2023.11.001

JingLin Zhu , FangNing Zhao , XueFeng Han, FaCheng Li

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引用次数: 0

Abstract

Background

This research probed the relevant mechanism of miR-379-3p by regulating suppressor of cytokine signaling1 (SOCS1) in the processes of inflammation, oxidative stress, and angiogenesis in fat grafting. An increasing body of research indicates the involvement of miRNA/mRNA pathways in the process of fat transplantation, yet the underlying molecular mechanisms remain to be fully elucidated.

Results

miR-379-3p knockdown improved the survival rate of adipocytes, promoted adipose tissue angiogenesis, and reduced inflammation and oxidative stress levels. miR-379-3p targeted SOCS1. SOCS1 upregulation improved adipose tissue survival and angiogenesis and reduced inflammation. miR-379-3p affected adipose tissue survival, angiogenesis, and inflammation by targeting SOCS1 expression.

Conclusions

miR-379-3p inhibits fat grafting survival and angiogenesis by targeting SOCS1 to mediate adipose inflammation, suffering a novel way to improve fat grafting technique development.

How to cite: Zhu J, Zhao F, Han X, et al. miR-379-3p inhibits fat grafting survival and angiogenesis by targeting SOCS1-mediated adipose inflammation. Electron J Biotechnol 2024:67. https://doi.org/10.1016/j.ejbt.2023.11.001.

Abstract Image

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miR-379-3p通过靶向socs1介导的脂肪炎症抑制脂肪移植存活和血管生成

本研究通过调节细胞因子信号通路抑制因子1 (SOCS1)在脂肪移植炎症、氧化应激和血管生成过程中的作用，探讨miR-379-3p的相关机制。越来越多的研究表明miRNA/mRNA通路参与脂肪移植过程，但其潜在的分子机制仍未完全阐明。结果mir -379-3p敲低可提高脂肪细胞存活率，促进脂肪组织血管生成，降低炎症和氧化应激水平。miR-379-3p靶向SOCS1。SOCS1上调可改善脂肪组织存活和血管生成，减少炎症。miR-379-3p通过靶向SOCS1表达影响脂肪组织存活、血管生成和炎症。结论smir -379-3p通过靶向SOCS1介导脂肪炎症抑制脂肪移植存活和血管生成，为脂肪移植技术的发展提供了一条新的途径。

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来源期刊

Electronic Journal of Biotechnology 工程技术-生物工程与应用微生物

CiteScore

5.60

自引率

0.00%

发文量

审稿时长

2 months

期刊介绍： Electronic Journal of Biotechnology is an international scientific electronic journal, which publishes papers from all areas related to Biotechnology. It covers from molecular biology and the chemistry of biological processes to aquatic and earth environmental aspects, computational applications, policy and ethical issues directly related to Biotechnology. The journal provides an effective way to publish research and review articles and short communications, video material, animation sequences and 3D are also accepted to support and enhance articles. The articles will be examined by a scientific committee and anonymous evaluators and published every two months in HTML and PDF formats (January 15th , March 15th, May 15th, July 15th, September 15th, November 15th). The following areas are covered in the Journal: • Animal Biotechnology • Biofilms • Bioinformatics • Biomedicine • Biopolicies of International Cooperation • Biosafety • Biotechnology Industry • Biotechnology of Human Disorders • Chemical Engineering • Environmental Biotechnology • Food Biotechnology • Marine Biotechnology • Microbial Biotechnology • Molecular Biology and Genetics •Nanobiotechnology • Omics • Plant Biotechnology • Process Biotechnology • Process Chemistry and Technology • Tissue Engineering