Design of layer-by-layer lipid-polymer hybrid nanoparticles to elicit oral bioavailability of buspirone hydrochloride

IF 2.5 4区医学 Q4 MATERIALS SCIENCE, BIOMATERIALS

International Journal of Polymeric Materials and Polymeric Biomaterials Pub Date : 2023-09-11 DOI:10.1080/00914037.2023.2255720

Pankaj Dangre, Kajal Sonawane, Kailas Moravkar, Anil Pethe, Shailesh Chalikwar, Vivek Borse

引用次数: 0

Abstract

Polyelectrolyte multilayer (PEM) was developed through layer-by-layer (LbL) adsorption on sodium alginate on negatively charged lipid polymer hybrid nanoparticles (LPHNPs) for the delivery of Buspirone hydrochloride (BUH). The resultant BUH-LPHNPs (F2) showed a mean particle size of 166 ± 4.2 nm and zeta potential of −30.5 ± 1.52 mV. The BUH-LPHNPs were found to be stable and demonstrated controlled drug release kinetics. Further, the pharmacokinetic studies revealed a 3.29-fold rise in the oral bioavailability of formulation (F2) than BUH (pure). Thus, PEM fabricated through LbL technology could be explored for overcoming the bioavailability issue and targeted delivery for potential drug candidates.

查看原文本刊更多论文

设计一层一层的脂质-聚合物杂化纳米颗粒以获得盐酸丁螺环酮的口服生物利用度

摘要采用带负电荷的脂质聚合物杂化纳米粒子(LPHNPs)对海藻酸钠进行层层吸附，制备聚电解质多层膜(PEM)，用于递送盐酸丁螺环酮(BUH)。合成的BUH-LPHNPs (F2)平均粒径为166±4.2 nm, zeta电位为−30.5±1.52 mV。发现BUH-LPHNPs是稳定的，并表现出药物释放动力学控制。此外，药代动力学研究显示，制剂(F2)的口服生物利用度比BUH(纯)高3.29倍。因此，通过LbL技术制备的PEM可用于克服潜在候选药物的生物利用度问题和靶向递送。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

International Journal of Polymeric Materials and Polymeric Biomaterials Chemical Engineering-General Chemical Engineering

CiteScore

8.00

自引率

3.10%

发文量

审稿时长

3.3 months

期刊介绍： International Journal of Polymeric Materials and Polymeric Biomaterials is the official publication of the International Society for Biomedical Polymers and Polymeric Biomaterials (ISBPPB). This journal provides a forum for the publication of peer-reviewed, English language articles and select reviews on all aspects of polymeric materials and biomedical polymers. Being interdisciplinary in nature, this journal publishes extensive contributions in the areas of encapsulation and controlled release technologies to address innovation needs as well.