Mathematical Analysis of the Healthcare Treatment of 215 Patients with Coronary Heart Disease

IF 2.6 2区 生物学 Q3 CELL BIOLOGY
Meiyi Tao, Shengli Sun, Yuelan Qin, Juan Wu, Yimin Cai, Dandan Li, Ke Tang, Ling Li, Shuang Wu
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Abstract

The main risk factors for CHD and the comorbidity include hyperlipidemia (HL), hypertension, smoking, dietary factors, and genetic factors. In this work, 215 patients with coronary heart disease, including 128 males and 87 females, were analyzed for a better understanding of the related clinical pharmacology. Nonparametric test, analysis of variance, chi-square test, correlation analysis, and other methods were used to sort out the data. From the analysis, there are significant differences in age among different gender samples. The incidence of coronary heart disease in men is five years younger than that in women. The sample pairs from different regions showed differences in the presence of family history of diabetes, indicating that a series of patients in some regions concentrated on the disease status of family history of diabetes. Age has a significant positive effect on cardiac functional classification. The older you are, the larger the cardiac functional classification is and the worse the cardiac function is. Age was negatively correlated with VTE score, diastolic blood pressure, CAR, TG, neutrophil, and TC. The older you are, the lower these six values are. Samples of different types of CHD showed significant differences in the presence of comorbidity and family history of CHD. The most significant are unstable angina pectoris and ischemic cardiomyopathy. Samples of different CHD types showed significant effects on VTE score, creatine kinase, low-density lipoprotein cholesterol (LDL⁃C), and lactate dehydrogenase. The highest lactate dehydrogenase is ischemic cardiomyopathy. The highest LDL cholesterol is ST-segment elevation angina. The highest creatine kinase is ischemic cardiomyopathy. The VTE score was the highest for ischemic cardiomyopathy, followed by non-ST-segment elevation angina. Samples taken with or without lipid-lowering drugs showed significant differences in lactate dehydrogenase, creatinine, and TC. There was a significant positive correlation between VTE scores and lactate dehydrogenase, myoglobin, and creatine kinase. High VTE score indicates high lactate dehydrogenase, myoglobin, and creatine kinase. TC has a significant positive correlation with HDL⁃C and TG, respectively. Higher TC values indicate higher HDL⁃C and TG values.
215例冠心病保健治疗的数学分析
冠心病及其合并症的主要危险因素包括高脂血症(HL)、高血压、吸烟、饮食因素和遗传因素。为了更好地了解相关临床药理学,本研究对215例冠心病患者进行了分析,其中男性128例,女性87例。采用非参数检验、方差分析、卡方检验、相关分析等方法对数据进行整理。从分析来看,不同性别样本的年龄存在显著差异。男性冠心病的发病率比女性小5岁。不同地区的样本对存在糖尿病家族史存在差异,说明部分地区的系列患者集中关注糖尿病家族史的疾病状况。年龄对心功能分级有显著的正向影响。年龄越大,心功能分类越大心功能越差。年龄与VTE评分、舒张压、CAR、TG、中性粒细胞、TC呈负相关。年龄越大,这六个值越低。不同类型冠心病样本在冠心病合并症和家族史方面存在显著差异。最显著的是不稳定型心绞痛和缺血性心肌病。不同冠心病类型对VTE评分、肌酸激酶、低密度脂蛋白胆固醇(LDL⁃C)和乳酸脱氢酶均有显著影响。乳酸脱氢酶最高的是缺血性心肌病。LDL胆固醇最高为st段抬高型心绞痛。肌酸激酶最高的是缺血性心肌病。缺血性心肌病的VTE评分最高,其次是非st段抬高型心绞痛。服用或不服用降脂药物的样本显示乳酸脱氢酶、肌酐和TC有显著差异。VTE评分与乳酸脱氢酶、肌红蛋白和肌酸激酶呈正相关。VTE评分高表明乳酸脱氢酶、肌红蛋白和肌酸激酶高。TC分别与HDL⁃C和TG呈显著正相关。TC值越高,说明HDL⁃C和TG值越高。
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来源期刊
Cellular Microbiology
Cellular Microbiology 生物-微生物学
CiteScore
9.70
自引率
0.00%
发文量
26
审稿时长
3 months
期刊介绍: Cellular Microbiology aims to publish outstanding contributions to the understanding of interactions between microbes, prokaryotes and eukaryotes, and their host in the context of pathogenic or mutualistic relationships, including co-infections and microbiota. We welcome studies on single cells, animals and plants, and encourage the use of model hosts and organoid cultures. Submission on cell and molecular biological aspects of microbes, such as their intracellular organization or the establishment and maintenance of their architecture in relation to virulence and pathogenicity are also encouraged. Contributions must provide mechanistic insights supported by quantitative data obtained through imaging, cellular, biochemical, structural or genetic approaches.
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