Investigating the Influence of Heterogeneity Within Cell Types on Microvessel Network Transport

IF 2.3 4区医学 Q3 BIOPHYSICS

Cellular and molecular bioengineering Pub Date : 2023-11-29 DOI:10.1007/s12195-023-00790-y

Junyu Nan, Sayan Roychowdhury, Amanda Randles

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Abstract

Background

Current research on the biophysics of circulating tumor cells often overlooks the heterogeneity of cell populations, focusing instead on average cellular properties. This study aims to address the gap by considering the diversity of cell biophysical characteristics and their implications on cancer spread.

Methods

We utilized computer simulations to assess the influence of variations in cell size and membrane elasticity on the behavior of cells within fluid environments. The study controlled cell and fluid properties to systematically investigate the transport of tumor cells through a simulated network of branching channels.

Results

The simulations revealed that even minor differences in cellular properties, such as slight changes in cell radius or shear elastic modulus, lead to significant changes in the fluid conditions that cells experience, including velocity and wall shear stress (p < 0.001).

Conclusion

The findings underscore the importance of considering cell heterogeneity in biophysical studies and suggest that small variations in cellular characteristics can profoundly impact the dynamics of tumor cell circulation. This has potential implications for understanding the mechanisms of cancer metastasis and the development of therapeutic strategies.

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研究细胞类型异质性对微血管网络运输的影响

当前关于循环肿瘤细胞生物物理学的研究往往忽略了细胞群的异质性，而将重点放在平均细胞特性上。本研究旨在通过考虑细胞生物物理特性的多样性及其对癌症扩散的影响来解决这一差距。方法利用计算机模拟方法研究细胞大小和膜弹性的变化对细胞在流体环境中行为的影响。该研究控制了细胞和流体特性，系统地研究了肿瘤细胞通过模拟分支通道网络的运输。模拟结果显示，即使细胞性质的微小差异，如细胞半径或剪切弹性模量的微小变化，也会导致细胞所经历的流体条件发生显著变化，包括速度和壁面剪切应力(p < 0.001)。结论这些发现强调了在生物物理研究中考虑细胞异质性的重要性，并表明细胞特性的微小变化可以深刻影响肿瘤细胞循环的动力学。这对理解癌症转移的机制和制定治疗策略具有潜在的意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cellular and molecular bioengineering 生物-生物物理

CiteScore

5.60

自引率

3.60%

发文量

审稿时长

>12 weeks

期刊介绍： The field of cellular and molecular bioengineering seeks to understand, so that we may ultimately control, the mechanical, chemical, and electrical processes of the cell. A key challenge in improving human health is to understand how cellular behavior arises from molecular-level interactions. CMBE, an official journal of the Biomedical Engineering Society, publishes original research and review papers in the following seven general areas: Molecular: DNA-protein/RNA-protein interactions, protein folding and function, protein-protein and receptor-ligand interactions, lipids, polysaccharides, molecular motors, and the biophysics of macromolecules that function as therapeutics or engineered matrices, for example. Cellular: Studies of how cells sense physicochemical events surrounding and within cells, and how cells transduce these events into biological responses. Specific cell processes of interest include cell growth, differentiation, migration, signal transduction, protein secretion and transport, gene expression and regulation, and cell-matrix interactions. Mechanobiology: The mechanical properties of cells and biomolecules, cellular/molecular force generation and adhesion, the response of cells to their mechanical microenvironment, and mechanotransduction in response to various physical forces such as fluid shear stress. Nanomedicine: The engineering of nanoparticles for advanced drug delivery and molecular imaging applications, with particular focus on the interaction of such particles with living cells. Also, the application of nanostructured materials to control the behavior of cells and biomolecules.

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