Rh(I)-catalyzed enantioselective (3 + 2) transannulations of 1,2,3-thiadiazoles with P-chiral monodentate phosphines

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-02-01 DOI:10.1080/10426507.2023.2281473

Hao Wei , Cunzhi Chen , Aijun Gao , Zhanhui Yang

引用次数: 0

Abstract

As a proof of concept, P-chiral monodentate phosphines, which were inactive in promoting the transannulations of 1,2,3-thiadiazoles, were proven viable in the asymmetric catalytic (3 + 2) transannulations of 1,2,3-thiadiazoles with a strained bicyclic alkene. Polycyclic dihydrothiophenes with four newly formed stereocenters are generated in moderate 19-72% yields and 11-27% enantiopurities.

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Rh(I)催化1,2,3-噻二唑与p -手性单齿膦的对映选择性(3 + 2)转环反应

作为概念的证明，p手性单齿膦在促进1,2,3-噻二唑的转环反应中没有活性，但在不对称催化(3 + 2)转环反应中是可行的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.