Xuan Zhao, Junfeng Cheng, Lu Zhang, Baofeng Yun, Kui Yan, Bin Wu, Xiao Liu, Fan Zhang, Zuhai Lei
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引用次数: 0
Abstract
Small-molecule fluorophores in the second near-infrared window (NIR-II, 1,000–1,700 nm) have received widespread attention owing to their great breakthrough in deep-tissue imaging with high spatial resolution, but the strategies used to construct NIR-II fluorescent scaffolds are still very limited. Here, we report a pathway toward NIR-II wavelength-emissive fluorescent dyes, namely diphenylaminoacridine (DPA) dyes, with large Stokes shifts based on the planarized intramolecular charge transfer mechanism. DPAs exhibit tunable optical properties with the maximal absorption/emission wavelengths at 900 nm and 1,085 nm. They show high tolerance toward both photobleaching and oxidation. The in vivo gastrointestinal tract with high resolution demonstrates their significant potential in bioimaging. Overall, this work provides a promising avenue to construct NIR-II small-molecule fluorescent scaffolds for bioimaging.
期刊介绍：
Cell Reports Physical Science, a premium open-access journal from Cell Press, features high-quality, cutting-edge research spanning the physical sciences. It serves as an open forum fostering collaboration among physical scientists while championing open science principles. Published works must signify significant advancements in fundamental insight or technological applications within fields such as chemistry, physics, materials science, energy science, engineering, and related interdisciplinary studies. In addition to longer articles, the journal considers impactful short-form reports and short reviews covering recent literature in emerging fields. Continually adapting to the evolving open science landscape, the journal reviews its policies to align with community consensus and best practices.
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