Calcitonin gene-related peptide and persistent corneal pain: A trigeminal nerve sensitization perspective

Brain-X Pub Date : 2023-12-06 DOI:10.1002/brx2.48
Xiaoping Hong, Fadian Ding, Jie Xiong, Yuyu Wu, Wanzhu Chen
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Abstract

Persistent corneal pain (PCP) has excellent research prospects, especially the central sensitization mechanism of the trigeminal nerve, which is involved in migraine, corneal pain, and trigeminal neuralgia. The cornea has dense sensory innervation, and repeated corneal neuropathic pain has been associated with trigeminal nerve central sensitization, which is induced in PCP. The calcitonin gene-related peptide (CGRP) is involved in corneal pain conduction, injury protection, and immune homeostasis. A high CGRP level maintains corneal pain perception and protects corneal epithelial cells. However, a persistently high CGRP level causes hypersensitivity of the corneal and trigeminal nerves, resulting in PCP. CGRP-related drugs can effectively improve trigeminal nerve sensitization and relieve central sensitization-related pain (PCP, migraine, and trigeminal neuralgia). Exploring the role of CGRP in PCP's pain sensitization mechanism is vital in the pain perception field, with the potential to improve the quality of life of patients with PCP and strengthen the understanding of CGRP's dual role in corneal pain.

Abstract Image

降钙素基因相关肽与持续性角膜疼痛:三叉神经致敏的观点
持续性角膜疼痛(Persistent corneal pain, PCP)具有很好的研究前景,尤其是三叉神经中枢致敏机制,涉及偏头痛、角膜疼痛、三叉神经痛。角膜有密集的感觉神经支配,反复的角膜神经性疼痛与PCP诱导的三叉神经中枢致敏有关。降钙素基因相关肽(CGRP)参与角膜疼痛传导、损伤保护和免疫稳态。高水平的CGRP维持角膜疼痛感知并保护角膜上皮细胞。然而,持续高水平的CGRP会引起角膜和三叉神经的超敏反应,从而导致PCP。cgrp相关药物可有效改善三叉神经致敏,缓解中枢致敏相关疼痛(PCP、偏头痛、三叉神经痛)。探索CGRP在PCP疼痛致敏机制中的作用在疼痛感知领域至关重要,有可能改善PCP患者的生活质量,并加强对CGRP在角膜疼痛中的双重作用的理解。
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