Adhesion of vessel wall to stentriever during combined technique for mechanical thrombectomy in acute ischemic stroke: A histomorphological study.

IF 1.5 4区医学 Q4 CLINICAL NEUROLOGY

Interventional Neuroradiology Pub Date : 2023-12-06 DOI:10.1177/15910199231216764

Frank Donnerstag, Christopher Werlein, Friedrich Götz, Omar Abu Fares, Peter Raab, Enrico Calvino Iglesias, Heinrich Lanfermann, Mike P Wattjes, Danny Jonigk

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引用次数: 0

Abstract

Purpose: Detection of vessel wall tissue in thrombus material in patients with ischemic stroke is judged as vascular injury. So far, several studies investigated components of the free clots after mechanical thrombectomy. The aim of this retrospective study was to investigate the involvement and role of the stentriever in vessel wall injury by analysis of the composition of adherent tissue to the stentriever during combined aspiration thrombectomy with stentriever.

Methods: Stentriever with adherent tissue and free clots in aspiration samples from patients undergoing mechanical thrombectomy (aspiration plus stentriever) were separately assessed for the occurrence of parts of vascular tissue together with clinical and interventional data as well as clinical outcome data. Specimens were analyzed histomorphologically and immunohistochemically. Findings, focused on parts of vessel wall were reported together with clinical data.

Results: Specimens from 21 identified patients were available. Parts of the vessel wall were detected in 7 out 21 (33%) samples. All specimens revealed fresh thrombus material without signs of organization or atheromatous tissue. In 90% of patients mTICI was greater than 2b without signs of secondary vessel injury. No vascular tissue was found in free clots of the aspiration samples.

Conclusion: The examination of adherent tissue to the stentriever instead of the examination of free clots may affect the number of detected parts of vessel wall. Further studies in combination with vessel wall imaging may elucidate the origin of remnants of vessel wall.

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急性缺血性脑卒中联合机械取栓术中血管壁与增张剂的粘连:组织形态学研究。

目的:检测缺血性脑卒中患者血栓物质中的血管壁组织，判断其为血管损伤。到目前为止，有几项研究调查了机械取栓后游离凝块的成分。本回顾性研究的目的是通过分析吸入性取栓联合吸入性取栓术中吸入性取栓剂粘附组织的组成，探讨吸入性取栓剂在血管壁损伤中的作用。方法:分别评估机械取栓患者(抽吸加施张剂)抽吸标本中施张剂粘附组织和游离凝块的部分血管组织的发生情况，并结合临床和介入性资料及临床结局资料。对标本进行组织形态学和免疫组织化学分析。研究结果集中于部分血管壁，并与临床资料一起报道。结果:获得21例经鉴定的患者标本。21个样本中有7个(33%)检测到部分血管壁。所有标本显示新鲜血栓物质，没有组织或动脉粥样硬化组织的迹象。90%的患者mTICI大于2b，无继发性血管损伤迹象。在抽吸样本的游离凝块中未发现血管组织。结论:用血管壁贴壁组织检查代替游离血块检查可能会影响血管壁检测部位的数量。进一步的研究结合血管壁成像可以阐明血管壁残余物的来源。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Interventional Neuroradiology CLINICAL NEUROLOGY-RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

CiteScore

3.60

自引率

11.80%

发文量

192

审稿时长

6-12 weeks

期刊介绍： Interventional Neuroradiology (INR) is a peer-reviewed clinical practice journal documenting the current state of interventional neuroradiology worldwide. INR publishes original clinical observations, descriptions of new techniques or procedures, case reports, and articles on the ethical and social aspects of related health care. Original research published in INR is related to the practice of interventional neuroradiology...