Clinical characteristics of suicidal behavior in first hospitalization and drug-naïve patients with major depressive disorder.

IF 3.6 3区医学 Q1 PSYCHIATRY

Annals of General Psychiatry Pub Date : 2023-12-06 DOI:10.1186/s12991-023-00484-9

Xianzhi Sun, Lili Yin, Yingying Zhang, Xuebing Liu, Jun Ma

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Abstract

Background: Major depressive disorder (MDD) is a major and common cause of suicide. The purpose of this article is to report the clinical characteristics and patterns of co-morbid suicidal behavior (SB) in first hospitalized and drug-naïve MDD patients.

Methods: A total of 345 patients with first hospitalization and drug-naïve MDD with SB were included in this study, while 183 patients without SB were included as a control group. We collected socio-demographic, general clinical data and common biochemical indicators of all participants and assessed their clinical symptoms.

Results: Compared to patients without SB, MDD with SB had more severe clinical symptoms and worse metabolic indicators. Duration of disease, depressive symptom scores, and thyroid stimulating hormone (TSH) levels was risk factors for SB and its number.

Conclusions: MDD patients with SB suffered more severe clinical symptoms and worse metabolic indicators, and risk factors for SB in this population were identified, which may provide beneficial insight and reference for clinical prevention and intervention of SB in MDD patients.

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首次住院及drug-naïve重性抑郁症患者自杀行为的临床特征

背景:重度抑郁障碍(MDD)是自杀的主要和常见原因。本文的目的是报告首次住院和drug-naïve MDD患者共病自杀行为(SB)的临床特征和模式。方法:本研究共纳入345例首次住院drug-naïve伴SB的重度抑郁症患者，183例无SB患者作为对照组。我们收集了所有参与者的社会人口学、一般临床资料和常见生化指标，并评估了他们的临床症状。结果:与无SB患者相比，伴有SB的MDD患者临床症状更严重，代谢指标更差。病程、抑郁症状评分和促甲状腺激素(TSH)水平是SB及其数量的危险因素。结论:MDD合并SB患者临床症状更严重，代谢指标更差，明确了该人群SB的危险因素，为MDD患者SB的临床预防和干预提供有益的见解和参考。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annals of General Psychiatry PSYCHIATRY-

CiteScore

6.60

自引率

2.70%

发文量

审稿时长

>12 weeks

期刊介绍： Annals of General Psychiatry considers manuscripts on all aspects of psychiatry, including neuroscience and psychological medicine. Both basic and clinical neuroscience contributions are encouraged. Annals of General Psychiatry emphasizes a biopsychosocial approach to illness and health and strongly supports and follows the principles of evidence-based medicine. As an open access journal, Annals of General Psychiatry facilitates the worldwide distribution of high quality psychiatry and mental health research. The journal considers submissions on a wide range of topics including, but not limited to, psychopharmacology, forensic psychiatry, psychotic disorders, psychiatric genetics, and mood and anxiety disorders.