Andrea Lips, Erika Calvano Küchler, Isabela Ribeiro Madalena, Patricia Nivoloni Tannure, Leonardo Santos Antunes, Livia Azeredo Alves Antunes, Marcelo Castro Costa, Peter Proff, Christian Kirschneck, Flares Baratto-Filho
{"title":"Non-syndromic supernumerary teeth and association with a self-reported family history of cancer.","authors":"Andrea Lips, Erika Calvano Küchler, Isabela Ribeiro Madalena, Patricia Nivoloni Tannure, Leonardo Santos Antunes, Livia Azeredo Alves Antunes, Marcelo Castro Costa, Peter Proff, Christian Kirschneck, Flares Baratto-Filho","doi":"10.1007/s00056-023-00504-z","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Supernumerary teeth are an alteration of dental developmental and result in the formation of teeth above the usual number. Epidemiologic studies suggested that patients with dentofacial anomalies and their family members may present an increased risk of developing cancer, including female breast cancer and gynecologic cancers. These observations indicate that genetic alterations that result in dental anomalies may be related to cancer development. Thus, the aim of the present study was to evaluate the association between supernumerary teeth and a family history of female breast cancer and gynecologic cancers.</p><p><strong>Methods: </strong>The diagnosis of supernumerary teeth was based on clinical and radiographic examinations. For data collection, a questionnaire asking for information regarding ethnicity, age, gender, and self-reported family history of cancer up to the second generation was used. Statistical analysis was performed using the Χ<sup>2</sup> test and Fisher's exact test with an established α of 5%.</p><p><strong>Results: </strong>A total of 344 patients were included; 47 of them had one or more non-syndromic supernumerary teeth (not associated with any syndrome or cleft lip and palate) and 297 were control patients. Age, ethnicity, and gender distribution were not statistically different between the group with supernumerary teeth and the control group (p > 0.05). The supernumerary teeth were most commonly observed in the incisors area. Breast cancer (n = 17) was the most commonly self-reported type of cancer, followed by uterine cervical (n = 10), endometrial (n = 2), and ovarian (n = 1) cancers. Endometrial cancer was significantly associated with the diagnosis of supernumerary teeth (p = 0.017).</p><p><strong>Conclusion: </strong>This study suggests that patients with supernumerary teeth possess a higher risk of having family members with endometrial cancer.</p>","PeriodicalId":54776,"journal":{"name":"Journal of Orofacial Orthopedics-Fortschritte Der Kieferorthopadie","volume":null,"pages":null},"PeriodicalIF":1.3000,"publicationDate":"2023-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Orofacial Orthopedics-Fortschritte Der Kieferorthopadie","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s00056-023-00504-z","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"DENTISTRY, ORAL SURGERY & MEDICINE","Score":null,"Total":0}
引用次数: 0
Abstract
Background: Supernumerary teeth are an alteration of dental developmental and result in the formation of teeth above the usual number. Epidemiologic studies suggested that patients with dentofacial anomalies and their family members may present an increased risk of developing cancer, including female breast cancer and gynecologic cancers. These observations indicate that genetic alterations that result in dental anomalies may be related to cancer development. Thus, the aim of the present study was to evaluate the association between supernumerary teeth and a family history of female breast cancer and gynecologic cancers.
Methods: The diagnosis of supernumerary teeth was based on clinical and radiographic examinations. For data collection, a questionnaire asking for information regarding ethnicity, age, gender, and self-reported family history of cancer up to the second generation was used. Statistical analysis was performed using the Χ2 test and Fisher's exact test with an established α of 5%.
Results: A total of 344 patients were included; 47 of them had one or more non-syndromic supernumerary teeth (not associated with any syndrome or cleft lip and palate) and 297 were control patients. Age, ethnicity, and gender distribution were not statistically different between the group with supernumerary teeth and the control group (p > 0.05). The supernumerary teeth were most commonly observed in the incisors area. Breast cancer (n = 17) was the most commonly self-reported type of cancer, followed by uterine cervical (n = 10), endometrial (n = 2), and ovarian (n = 1) cancers. Endometrial cancer was significantly associated with the diagnosis of supernumerary teeth (p = 0.017).
Conclusion: This study suggests that patients with supernumerary teeth possess a higher risk of having family members with endometrial cancer.
期刊介绍:
The Journal of Orofacial Orthopedics provides orthodontists and dentists who are also actively interested in orthodontics, whether in university clinics or private practice, with highly authoritative and up-to-date information based on experimental and clinical research. The journal is one of the leading publications for the promulgation of the results of original work both in the areas of scientific and clinical orthodontics and related areas. All articles undergo peer review before publication. The German Society of Orthodontics (DGKFO) also publishes in the journal important communications, statements and announcements.