Non-syndromic supernumerary teeth and association with a self-reported family history of cancer.

IF 1.3 4区 医学 Q3 DENTISTRY, ORAL SURGERY & MEDICINE
Andrea Lips, Erika Calvano Küchler, Isabela Ribeiro Madalena, Patricia Nivoloni Tannure, Leonardo Santos Antunes, Livia Azeredo Alves Antunes, Marcelo Castro Costa, Peter Proff, Christian Kirschneck, Flares Baratto-Filho
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引用次数: 0

Abstract

Background: Supernumerary teeth are an alteration of dental developmental and result in the formation of teeth above the usual number. Epidemiologic studies suggested that patients with dentofacial anomalies and their family members may present an increased risk of developing cancer, including female breast cancer and gynecologic cancers. These observations indicate that genetic alterations that result in dental anomalies may be related to cancer development. Thus, the aim of the present study was to evaluate the association between supernumerary teeth and a family history of female breast cancer and gynecologic cancers.

Methods: The diagnosis of supernumerary teeth was based on clinical and radiographic examinations. For data collection, a questionnaire asking for information regarding ethnicity, age, gender, and self-reported family history of cancer up to the second generation was used. Statistical analysis was performed using the Χ2 test and Fisher's exact test with an established α of 5%.

Results: A total of 344 patients were included; 47 of them had one or more non-syndromic supernumerary teeth (not associated with any syndrome or cleft lip and palate) and 297 were control patients. Age, ethnicity, and gender distribution were not statistically different between the group with supernumerary teeth and the control group (p > 0.05). The supernumerary teeth were most commonly observed in the incisors area. Breast cancer (n = 17) was the most commonly self-reported type of cancer, followed by uterine cervical (n = 10), endometrial (n = 2), and ovarian (n = 1) cancers. Endometrial cancer was significantly associated with the diagnosis of supernumerary teeth (p = 0.017).

Conclusion: This study suggests that patients with supernumerary teeth possess a higher risk of having family members with endometrial cancer.

非综合征性超常牙齿及与自述癌症家族史的关系。
背景:超常牙是牙齿发育的一种改变,会形成超过正常数量的牙齿。流行病学研究表明,牙面畸形患者及其家庭成员罹患癌症(包括女性乳腺癌和妇科癌症)的风险可能会增加。这些观察结果表明,导致牙齿畸形的基因改变可能与癌症的发生有关。因此,本研究旨在评估超常牙齿与女性乳腺癌和妇科癌症家族史之间的关联:方法:根据临床和放射学检查来诊断超常牙齿。在收集数据时,使用了一份调查问卷,其中询问了有关种族、年龄、性别以及自述的第二代癌症家族史等信息。统计分析采用Χ2检验和费雪精确检验,α为5%:共纳入了 344 名患者,其中 47 人有一颗或多颗非综合征超常牙齿(与任何综合征或唇腭裂无关),297 人为对照组患者。在年龄、种族和性别分布方面,超常牙齿组与对照组没有统计学差异(P > 0.05)。超常牙齿最常见于门牙部位。乳腺癌(17 人)是最常自我报告的癌症类型,其次是子宫颈癌(10 人)、子宫内膜癌(2 人)和卵巢癌(1 人)。子宫内膜癌与超生牙的诊断有明显相关性(p = 0.017):结论:本研究表明,多生牙患者的家庭成员患子宫内膜癌的风险较高。
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来源期刊
CiteScore
3.90
自引率
0.00%
发文量
64
审稿时长
>12 weeks
期刊介绍: The Journal of Orofacial Orthopedics provides orthodontists and dentists who are also actively interested in orthodontics, whether in university clinics or private practice, with highly authoritative and up-to-date information based on experimental and clinical research. The journal is one of the leading publications for the promulgation of the results of original work both in the areas of scientific and clinical orthodontics and related areas. All articles undergo peer review before publication. The German Society of Orthodontics (DGKFO) also publishes in the journal important communications, statements and announcements.
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