[Cerebellar antibodies in post-stroke sera of acute ischemic stroke patients].

IF 0.9 4区医学 Q4 CLINICAL NEUROLOGY

Ideggyogyaszati Szemle-Clinical Neuroscience Pub Date : 2023-11-30 DOI:10.18071/isz.76.0394

Murat Mert Atmaca, Ece Erdağ, Serkan Demir, Hande Yüceer, Melek Çolak Atmaca, Cem İsmail Küçükali, Murat Kürtüncü, Erdem Tüzün

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引用次数: 0

Abstract

Background and purpose:

Although serum anti-neuronal antibodies are found in acute ischemic stroke (AIS) patients, it is not completely clear whether they are already present before the cerebrovascular event or emerge thereafter.

Methods:

Sera of 21 consecutive first-ever AIS patients were collected within the first day of AIS (baseline), as well as 1 and 6 months after AIS. Well-characterized and novel anti-neuronal antibodies were investigated by cell-based assays, immunoblotting and indirect immunohistochemistry.

Results:

None of the AIS sera collected at different time points showed well-characterized antibodies. In 7 patients, 1- and 6-month sera (but not baseline sera) showed IgG mostly reacting with soma and dendrites of cerebellar Purkinje cells. Antibody-positive patients did not differ in terms of clinical and etiological features.

Conclusion:

Our results provide evidence for the antibody-triggering action of AIS. Although anti-cerebellar antibodies are not associated with the severity of stroke, they may potentially contribute to chronic post-stroke complications and disability.

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[急性缺血性脑卒中患者卒中后血清中的小脑抗体]。

背景和目的：虽然在急性缺血性脑卒中（AIS）患者中发现了血清抗神经元抗体，但这些抗体是在脑血管事件发生前就已存在，还是在事件发生后才出现，目前尚不完全清楚：方法：连续收集了 21 名首次发病的 AIS 患者在 AIS 第一天（基线）以及 AIS 后 1 个月和 6 个月的血清。通过细胞检测法、免疫印迹法和间接免疫组化法对特征明确的新型抗神经元抗体进行了研究：在不同时间点采集的 AIS 血清均未显示特征明确的抗体。在 7 名患者中，1 个月和 6 个月的血清（而非基线血清）显示出主要与小脑浦肯野细胞的体节和树突反应的 IgG。抗体阳性患者在临床和病因学特征方面没有差异：我们的研究结果为 AIS 的抗体触发作用提供了证据。虽然抗小脑抗体与中风的严重程度无关，但它们有可能导致中风后的慢性并发症和残疾。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Ideggyogyaszati Szemle-Clinical Neuroscience CLINICAL NEUROLOGY-NEUROSCIENCES

CiteScore

1.30

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： The aim of Clinical Neuroscience (Ideggyógyászati Szemle) is to provide a forum for the exchange of clinical and scientific information for a multidisciplinary community. The Clinical Neuroscience will be of primary interest to neurologists, neurosurgeons, psychiatrist and clinical specialized psycholigists, neuroradiologists and clinical neurophysiologists, but original works in basic or computer science, epidemiology, pharmacology, etc., relating to the clinical practice with involvement of the central nervous system are also welcome.