Human blastoid as an in vitro model of human blastocysts

IF 3.7 2区 生物学 Q2 CELL BIOLOGY
Xiaodong Liu , Jose M Polo
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引用次数: 0

Abstract

Human development is a highly coordinated process, with any abnormalities during the early embryonic stages that can often have detrimental consequences. The complexity and nuances of human development underpin its significance in embryo research. However, this research is often hindered by limited availability and ethical considerations associated with the use of donated blastocysts from in vitro fertilization (IVF) surplus. Human blastoids offer promising alternatives as they can be easily generated and manipulated in the laboratory while preserving key characteristics of human blastocysts. In this way, they hold the potential to serve as a scalable and ethically permissible resource in embryology research. By utilizing such human embryo models, we can establish a transformative platform that complements the study with IVF embryos, ultimately enhancing our understanding of human embryogenesis.

作为人类囊胚体外模型的人类囊胚。
人类发育是一个高度协调的过程,胚胎早期阶段的任何异常都可能造成有害后果。人类发育的复杂性和细微差别决定了胚胎研究的重要性。然而,由于使用体外受精(IVF)剩余捐赠囊胚的可用性有限且存在伦理方面的考虑,这项研究往往受到阻碍。人类囊胚提供了很有前景的替代品,因为它们可以很容易地在实验室中生成和操作,同时保留人类囊胚的主要特征。因此,它们有可能成为胚胎学研究中可扩展且符合伦理要求的资源。通过利用这种人类胚胎模型,我们可以建立一个变革性平台,对体外受精胚胎研究进行补充,最终提高我们对人类胚胎发生的认识。
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来源期刊
CiteScore
7.90
自引率
0.00%
发文量
102
审稿时长
1 months
期刊介绍: Current Opinion in Genetics and Development aims to stimulate scientifically grounded, interdisciplinary, multi-scale debate and exchange of ideas. It contains polished, concise and timely reviews and opinions, with particular emphasis on those articles published in the past two years. In addition to describing recent trends, the authors are encouraged to give their subjective opinion of the topics discussed. In Current Opinion in Genetics and Development we help the reader by providing in a systematic manner: 1. The views of experts on current advances in their field in a clear and readable form. 2. Evaluations of the most interesting papers, annotated by experts, from the great wealth of original publications.[...] The subject of Genetics and Development is divided into six themed sections, each of which is reviewed once a year: • Cancer Genomics • Genome Architecture and Expression • Molecular and genetic basis of disease • Developmental mechanisms, patterning and evolution • Cell reprogramming, regeneration and repair • Genetics of Human Origin / Evolutionary genetics (alternate years)
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